TY - JOUR
T1 - Stroke
T2 - Understanding the differences between males and females
AU - Wilson, Melinda E.
PY - 2013/5
Y1 - 2013/5
N2 - Stroke is a significant cause of death and long-term disability in the USA. The incidence, mortality, and outcomes of stroke are significantly different between men and women. As with many diseases that affect men and women differently, an understanding on the reasons underlying those differences is critical to effective diagnosis and treatment. This review will examine the sex differences in stroke in both humans and animal models of stroke and review what is known about potential mechanisms underlying these differences. It is clear that there is a complex interaction between hormonal, genetic, and unknown factors at play in generating the sex differences in stroke.
AB - Stroke is a significant cause of death and long-term disability in the USA. The incidence, mortality, and outcomes of stroke are significantly different between men and women. As with many diseases that affect men and women differently, an understanding on the reasons underlying those differences is critical to effective diagnosis and treatment. This review will examine the sex differences in stroke in both humans and animal models of stroke and review what is known about potential mechanisms underlying these differences. It is clear that there is a complex interaction between hormonal, genetic, and unknown factors at play in generating the sex differences in stroke.
KW - Epigenetics
KW - Estrogen
KW - Gender
KW - Progesterone
KW - Stroke
KW - Testosterone
UR - http://www.scopus.com/inward/record.url?scp=84878017285&partnerID=8YFLogxK
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U2 - 10.1007/s00424-013-1260-x
DO - 10.1007/s00424-013-1260-x
M3 - Review article
C2 - 23503729
AN - SCOPUS:84878017285
SN - 0031-6768
VL - 465
SP - 595
EP - 600
JO - Pflugers Archiv European Journal of Physiology
JF - Pflugers Archiv European Journal of Physiology
IS - 5
ER -