Stromal Cell-Derived Factor 1-Mediated CXCR4 Signaling in Rat and Human Cortical Neural Progenitor Cells

Hui Peng, Yunlong Huang, Jeremy Rose, David Erichsen, Shelley Herek, Nobutaka Fujii, Hirokazu Tamamura, Jialin Zheng

Research output: Contribution to journalArticlepeer-review

150 Scopus citations


Stromal cell-derived factor 1 (SDF-1) and the chemokine receptor CXCR4 are highly expressed in the nervous system. Knockout studies have suggested that both SDF-1 and CXCR4 play essential roles in cerebellar, hippocampal, and neocortical neural cell migration during embryogenesis. To extend these observations, CXCR4 signaling events in rat and human neural progenitor cells (NPCs) were examined. Our results show that CXCR4 is expressed in abundance on rat and human NPCs. Moreover, SDF-1α induced increased NPCs levels of inositol 1,4,5-triphosphate, extracellular signal-regulated kinases 1/2, Akt, c-Jun N-terminal kinase, and intracellular calcium whereas it diminished cyclic adenosine monophosphate. Finally, SDF-1α can induce human NPC chemotaxis in vitro, suggesting that CXCR4 plays a functional role in NPC migration. Both T140, a CXCR4 antagonist, and pertussis toxin (PTX), an inactivator of G protein-coupled receptors, abrogated these events. Ultimately, this study suggested that SDF-1α can influence NPC function through CXCR4 and that CXCR4 is functional on NPC.

Original languageEnglish
Pages (from-to)35-50
Number of pages16
JournalJournal of Neuroscience Research
Issue number1
StatePublished - Apr 1 2004


  • CXCR4
  • Intracellular signaling
  • Neural progenitor cell
  • Neurogenesis
  • SDF-1α

ASJC Scopus subject areas

  • Cellular and Molecular Neuroscience


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