Structural Isomerization of 2-Anilinonicotinic Acid Leads to a New Synthon in 6-Anilinonicotinic Acids

Siqing Peng, Faquan Yu, Danrui Xu, Conggang Li, Sean R. Parkin, Tonglei Li, Mingtao Zhang, Sihui Long

Research output: Contribution to journalArticlepeer-review

3 Scopus citations

Abstract

Through structural modification of 2-anilinonicotinic acid by isomerization, a new synthon, acid-aminopyridine, is created, and the two original synthons, i.e., the acid-acid homosynthon and acid-pyridine heterosynthon are no longer observed in the newly designed 6-anilinonicotinic acids. The new synthon has a hydrogen-bond strength rivaling that of the acid-acid homosynthon and the acid-pyridine heterosynthon, as suggested by theoretical calculations, which explains its formation.

Original languageEnglish
Pages (from-to)4849-4859
Number of pages11
JournalCrystal Growth and Design
Volume18
Issue number9
DOIs
StatePublished - Sep 5 2018

Bibliographical note

Publisher Copyright:
Copyright © 2018 American Chemical Society.

ASJC Scopus subject areas

  • General Chemistry
  • General Materials Science
  • Condensed Matter Physics

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