Structure-activity relationships of elloramycin and tetracenomycin C

Jürgen Rohr, Axel Zeeck

Research output: Contribution to journalArticlepeer-review

25 Scopus citations


The structure-activity relationships of the anthracycline-related antibiotics of the tetracenomycin C/elloramycin-type were investigated by derivatization of elloramycin (1) and elloramycinone (2). During hydrolysis experiments a unique transglycosylation reaction was discovered, converting elloramycin (1) into isoelloramycin (10) by treatment with anhydrous trifluoroacetic acid. Following the proposed structure-activity relationship concept, 8-O-methylelloramycinone (14) was synthesized from elloramycinone (2), and was shown to be the most active derivative according to the proliferation inhibition assay against murine L1210 leukemia cells.

Original languageEnglish
Pages (from-to)1169-1178
Number of pages10
JournalJournal of Antibiotics
Issue number9
StatePublished - 1990

ASJC Scopus subject areas

  • Pharmacology
  • Drug Discovery


Dive into the research topics of 'Structure-activity relationships of elloramycin and tetracenomycin C'. Together they form a unique fingerprint.

Cite this