Structure-based gene targeting discovery of sphaerimicin, a bacterial translocase i inhibitor

Masanori Funabashi, Satoshi Baba, Toshio Takatsu, Masaaki Kizuka, Yasuo Ohata, Masahiro Tanaka, Koichi Nonaka, Anatol P. Spork, Christian Ducho, Wei Chen Leyla Chen, Steven G. Van Lanen

Research output: Contribution to journalArticlepeer-review

27 Scopus citations

Abstract

Rise and shine: Using a gene-targeting approach aimed at identifying potential L-threonine:uridine-5′-transaldolases that catalyze the formation of (5′S,6′S)-C-glycyluridine, a new bacterial translocase I inhibitor was discovered from an actinomycete following fermentation optimization.

Original languageEnglish
Pages (from-to)11607-11611
Number of pages5
JournalAngewandte Chemie - International Edition
Volume52
Issue number44
DOIs
StatePublished - Oct 25 2013

Keywords

  • actinomycetes
  • bacterial translocase I inhibitor
  • gene targeting
  • nucleoside antibiotics
  • transaldolase

ASJC Scopus subject areas

  • Catalysis
  • General Chemistry

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