TY - JOUR
T1 - Structure-based gene targeting discovery of sphaerimicin, a bacterial translocase i inhibitor
AU - Funabashi, Masanori
AU - Baba, Satoshi
AU - Takatsu, Toshio
AU - Kizuka, Masaaki
AU - Ohata, Yasuo
AU - Tanaka, Masahiro
AU - Nonaka, Koichi
AU - Spork, Anatol P.
AU - Ducho, Christian
AU - Chen, Wei Chen Leyla
AU - Van Lanen, Steven G.
PY - 2013/10/25
Y1 - 2013/10/25
N2 - Rise and shine: Using a gene-targeting approach aimed at identifying potential L-threonine:uridine-5′-transaldolases that catalyze the formation of (5′S,6′S)-C-glycyluridine, a new bacterial translocase I inhibitor was discovered from an actinomycete following fermentation optimization.
AB - Rise and shine: Using a gene-targeting approach aimed at identifying potential L-threonine:uridine-5′-transaldolases that catalyze the formation of (5′S,6′S)-C-glycyluridine, a new bacterial translocase I inhibitor was discovered from an actinomycete following fermentation optimization.
KW - actinomycetes
KW - bacterial translocase I inhibitor
KW - gene targeting
KW - nucleoside antibiotics
KW - transaldolase
UR - https://www.scopus.com/pages/publications/84886070500
UR - https://www.scopus.com/pages/publications/84886070500#tab=citedBy
U2 - 10.1002/anie.201305546
DO - 10.1002/anie.201305546
M3 - Article
C2 - 24014169
AN - SCOPUS:84886070500
SN - 1433-7851
VL - 52
SP - 11607
EP - 11611
JO - Angewandte Chemie - International Edition
JF - Angewandte Chemie - International Edition
IS - 44
ER -