Studies on the anti-tumor effect of crocetin against benzo (a)pyrene induced lung cancer in Swiss albino mice

V. Magesh; P. Senthilnathan; P. Rajendran; D. Sakthisekaran

Studies on the anti-tumor effect of crocetin against benzo (a)pyrene induced lung cancer in Swiss albino mice

V. Magesh, P. Senthilnathan, P. Rajendran, D. Sakthisekaran

Internal Medicine

Research output: Contribution to journal › Article › peer-review

Abstract

Lung cancer is the leading cause of death worldwide. Its overall survival rate has improved only slightly; surgery, radiotherapy and chemotherapy remain the mainstays of current treatment. The effect of crocetin on benzo (a) pyrene B(a)P-induced lung carcinoma, antioxidant status were evaluated in mice intra peritoneal injection of crocetin (20 mg/kg body Wt)with B(a)P(50 mg/kg body wt) inhibited the tumor incidence in mice. These results indicate that crocetin posses as a potential cancer chemo preventive agent against tumor promotion.

Original language	English
Pages (from-to)	96-99
Number of pages	4
Journal	Biomedicine
Volume	23
Issue number	3-4
State	Published - 2003

Keywords

Antioxidant enzymes
Benzo (a) pyrene
Crocetin
Lung cancer

ASJC Scopus subject areas

General Biochemistry, Genetics and Molecular Biology

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Cite this

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title = "Studies on the anti-tumor effect of crocetin against benzo (a)pyrene induced lung cancer in Swiss albino mice",

abstract = "Lung cancer is the leading cause of death worldwide. Its overall survival rate has improved only slightly; surgery, radiotherapy and chemotherapy remain the mainstays of current treatment. The effect of crocetin on benzo (a) pyrene B(a)P-induced lung carcinoma, antioxidant status were evaluated in mice intra peritoneal injection of crocetin (20 mg/kg body Wt)with B(a)P(50 mg/kg body wt) inhibited the tumor incidence in mice. These results indicate that crocetin posses as a potential cancer chemo preventive agent against tumor promotion.",

keywords = "Antioxidant enzymes, Benzo (a) pyrene, Crocetin, Lung cancer",

author = "V. Magesh and P. Senthilnathan and P. Rajendran and D. Sakthisekaran",

year = "2003",

language = "English",

volume = "23",

pages = "96--99",

number = "3-4",

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TY - JOUR

T1 - Studies on the anti-tumor effect of crocetin against benzo (a)pyrene induced lung cancer in Swiss albino mice

AU - Magesh, V.

AU - Senthilnathan, P.

AU - Rajendran, P.

AU - Sakthisekaran, D.

PY - 2003

Y1 - 2003

N2 - Lung cancer is the leading cause of death worldwide. Its overall survival rate has improved only slightly; surgery, radiotherapy and chemotherapy remain the mainstays of current treatment. The effect of crocetin on benzo (a) pyrene B(a)P-induced lung carcinoma, antioxidant status were evaluated in mice intra peritoneal injection of crocetin (20 mg/kg body Wt)with B(a)P(50 mg/kg body wt) inhibited the tumor incidence in mice. These results indicate that crocetin posses as a potential cancer chemo preventive agent against tumor promotion.

AB - Lung cancer is the leading cause of death worldwide. Its overall survival rate has improved only slightly; surgery, radiotherapy and chemotherapy remain the mainstays of current treatment. The effect of crocetin on benzo (a) pyrene B(a)P-induced lung carcinoma, antioxidant status were evaluated in mice intra peritoneal injection of crocetin (20 mg/kg body Wt)with B(a)P(50 mg/kg body wt) inhibited the tumor incidence in mice. These results indicate that crocetin posses as a potential cancer chemo preventive agent against tumor promotion.

KW - Antioxidant enzymes

KW - Benzo (a) pyrene

KW - Crocetin

KW - Lung cancer

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M3 - Article

AN - SCOPUS:2142711108

SN - 0970-2067

VL - 23

SP - 96

EP - 99

JO - Biomedicine

JF - Biomedicine

IS - 3-4

ER -

Studies on the anti-tumor effect of crocetin against benzo (a)pyrene induced lung cancer in Swiss albino mice

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

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