Studying rod photoreceptor development in zebrafish

A. C. Morris; J. M. Fadool

doi:10.1016/j.physbeh.2005.08.020

Studying rod photoreceptor development in zebrafish

A. C. Morris, J. M. Fadool

Biology

Research output: Contribution to journal › Article › peer-review

49 Scopus citations

Abstract

The zebrafish has rapidly become a favored model vertebrate organism, well suited for studies of developmental processes using large-scale genetic screens. In particular, zebrafish morphological and behavioral genetic screens have led to the identification of genes important for development of the retinal photoreceptors. This may help clarify the genetic mechanisms underlying human photoreceptor development and dysfunction in retinal diseases. In this review, we present the advantages of zebrafish as a vertebrate model organism, summarize retinal and photoreceptor cell development in zebrafish, with emphasis on the rod photoreceptors, and describe zebrafish visual behaviors that can be used for genetic screens. We then describe some of the photoreceptor cell mutants that have been isolated in morphological and behavioral screens and discuss the limitations of current screening methods for uncovering mutations that specifically affect rod function. Finally, we present some alternative strategies to target the rod developmental pathway in zebrafish.

Original language	English
Pages (from-to)	306-313
Number of pages	8
Journal	Physiology and Behavior
Volume	86
Issue number	3
DOIs	https://doi.org/10.1016/j.physbeh.2005.08.020
State	Published - Oct 15 2005

Bibliographical note

Funding Information:
We would like to thank Mary Mullins, Michael Granato and their laboratory members for providing us with the embryos used in our pilot screen for rod photoreceptor mutants. This work was supported by NIH Grant EY13020.

Funding

We would like to thank Mary Mullins, Michael Granato and their laboratory members for providing us with the embryos used in our pilot screen for rod photoreceptor mutants. This work was supported by NIH Grant EY13020.

Funders	Funder number
National Institutes of Health (NIH)
National Eye Institute (NEI)	R01EY013020

Keywords

Genetics
Retinal development
Zebrafish

ASJC Scopus subject areas

Experimental and Cognitive Psychology
Behavioral Neuroscience

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.1016/j.physbeh.2005.08.020

Cite this

@article{01eb87154f4645c8af59a1fe363b6adc,

title = "Studying rod photoreceptor development in zebrafish",

abstract = "The zebrafish has rapidly become a favored model vertebrate organism, well suited for studies of developmental processes using large-scale genetic screens. In particular, zebrafish morphological and behavioral genetic screens have led to the identification of genes important for development of the retinal photoreceptors. This may help clarify the genetic mechanisms underlying human photoreceptor development and dysfunction in retinal diseases. In this review, we present the advantages of zebrafish as a vertebrate model organism, summarize retinal and photoreceptor cell development in zebrafish, with emphasis on the rod photoreceptors, and describe zebrafish visual behaviors that can be used for genetic screens. We then describe some of the photoreceptor cell mutants that have been isolated in morphological and behavioral screens and discuss the limitations of current screening methods for uncovering mutations that specifically affect rod function. Finally, we present some alternative strategies to target the rod developmental pathway in zebrafish.",

keywords = "Genetics, Retinal development, Zebrafish",

author = "Morris, {A. C.} and Fadool, {J. M.}",

note = "Funding Information: We would like to thank Mary Mullins, Michael Granato and their laboratory members for providing us with the embryos used in our pilot screen for rod photoreceptor mutants. This work was supported by NIH Grant EY13020.",

year = "2005",

month = oct,

day = "15",

doi = "10.1016/j.physbeh.2005.08.020",

language = "English",

volume = "86",

pages = "306--313",

number = "3",

}

TY - JOUR

T1 - Studying rod photoreceptor development in zebrafish

AU - Morris, A. C.

AU - Fadool, J. M.

N1 - Funding Information: We would like to thank Mary Mullins, Michael Granato and their laboratory members for providing us with the embryos used in our pilot screen for rod photoreceptor mutants. This work was supported by NIH Grant EY13020.

PY - 2005/10/15

Y1 - 2005/10/15

N2 - The zebrafish has rapidly become a favored model vertebrate organism, well suited for studies of developmental processes using large-scale genetic screens. In particular, zebrafish morphological and behavioral genetic screens have led to the identification of genes important for development of the retinal photoreceptors. This may help clarify the genetic mechanisms underlying human photoreceptor development and dysfunction in retinal diseases. In this review, we present the advantages of zebrafish as a vertebrate model organism, summarize retinal and photoreceptor cell development in zebrafish, with emphasis on the rod photoreceptors, and describe zebrafish visual behaviors that can be used for genetic screens. We then describe some of the photoreceptor cell mutants that have been isolated in morphological and behavioral screens and discuss the limitations of current screening methods for uncovering mutations that specifically affect rod function. Finally, we present some alternative strategies to target the rod developmental pathway in zebrafish.

AB - The zebrafish has rapidly become a favored model vertebrate organism, well suited for studies of developmental processes using large-scale genetic screens. In particular, zebrafish morphological and behavioral genetic screens have led to the identification of genes important for development of the retinal photoreceptors. This may help clarify the genetic mechanisms underlying human photoreceptor development and dysfunction in retinal diseases. In this review, we present the advantages of zebrafish as a vertebrate model organism, summarize retinal and photoreceptor cell development in zebrafish, with emphasis on the rod photoreceptors, and describe zebrafish visual behaviors that can be used for genetic screens. We then describe some of the photoreceptor cell mutants that have been isolated in morphological and behavioral screens and discuss the limitations of current screening methods for uncovering mutations that specifically affect rod function. Finally, we present some alternative strategies to target the rod developmental pathway in zebrafish.

KW - Genetics

KW - Retinal development

KW - Zebrafish

UR - http://www.scopus.com/inward/record.url?scp=26944495305&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=26944495305&partnerID=8YFLogxK

U2 - 10.1016/j.physbeh.2005.08.020

DO - 10.1016/j.physbeh.2005.08.020

M3 - Article

C2 - 16199068

AN - SCOPUS:26944495305

SN - 0031-9384

VL - 86

SP - 306

EP - 313

JO - Physiology and Behavior

JF - Physiology and Behavior

IS - 3

ER -

Studying rod photoreceptor development in zebrafish

Abstract

Bibliographical note

Funding

Keywords

ASJC Scopus subject areas

UN SDGs

Access to Document

Other files and links

Fingerprint

Cite this