Sub-second measurements of glutamate and other neurotransmitter signaling using enzyme-based ceramic microelectrode arrays

Erin R. Hascup, Kevin N. Hascup, Pooja M. Talauliker, David A. Price, Francois Pomerleau, Jorge E. Quintero, Peter Huettl, Alain Gratton, Ingrid Strömberg, Greg A. Gerhardt

Research output: Chapter in Book/Report/Conference proceedingConference contributionpeer-review

10 Scopus citations


We have set out to develop a novel, implantable microelectrode array that has the capabilities to detect neurotransmitters with enhanced sensitivity, selectivity, and temporal sampling capabilities compared to other current technologies. We have shown that this device maintains recording performance during chronic measurements of extracellular neurotransmitter levels for at least 7 days postimplantation, single-unit neuronal activity for as long as 6 months, and provides enhanced biocompatibility compared to current technologies. As we continue to refine and improve our recording capability, we are able to incorporate the chronic microelectrode array technology into multimodal experimental paradigms, such as behavioral testing, pharmacological intervention (local and systemic), or combined measurements of neurotransmitter levels and neuronal activity (local field potential). Furthermore, the improvements made with the microelectrode technology discussed in this chapter have the potential to conduct longitudinal analyses that can benefit a wide range of translational efforts, including studies on learning and memory, aging, neurodegenerative disease progression, and traumatic brain injury neuropathology.

Original languageEnglish
Title of host publicationMicroelectrode Biosensors
Number of pages21
StatePublished - 2013

Publication series

ISSN (Print)0893-2336
ISSN (Electronic)1940-6045


  • Behavior
  • Biosensor
  • Chronic
  • Glutamate
  • Histology
  • Neurochemistry

ASJC Scopus subject areas

  • Neuroscience (all)
  • Biochemistry, Genetics and Molecular Biology (all)
  • Pharmacology, Toxicology and Pharmaceutics (all)
  • Psychiatry and Mental health


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