Substances that can change alternative splice-site selection

Chiranthani Sumanasekera, David S. Watt, Stefan Stamm

Research output: Contribution to journalArticlepeer-review

53 Scopus citations

Abstract

Alternative pre-mRNA splicing is an important element in eukaryotic gene expression, as most of the protein-coding genes use this process to generate multiple protein isoforms from a single gene. An increasing number of human diseases are now recognized to be caused by the selection of 'wrong' alternative exons. Research during the last few years identified a number of low-molecular-mass chemical substances that can change alternative exon usage. Most of these substances act by either blocking histone deacetylases or by interfering with the phosphorylation of splicing factors. How the remaining large number of these substances affect splicing is not yet fully understood. The emergence of these low-molecular-mass substances provides not only probes for studying alternative pre-mRNA splicing, but also opens the door to the possible harnessing of these compounds as drugs to control diseases caused by the selection of 'wrong' splice sites.

Original languageEnglish
Pages (from-to)483-490
Number of pages8
JournalBiochemical Society Transactions
Volume36
Issue number3
DOIs
StatePublished - Jun 2008

Keywords

  • Alternative pre-mRNA splicing
  • Exon
  • Histone deacetylase inhibitor
  • Phosphorylation
  • Serine/arginine-rich protein
  • Splice-site selection

ASJC Scopus subject areas

  • Biochemistry

Fingerprint

Dive into the research topics of 'Substances that can change alternative splice-site selection'. Together they form a unique fingerprint.

Cite this