Substrate specificity of the macrolide-glycosylating enzyme pair DesVII/DesVIII: Opportunities, limitations, and mechanistic hypotheses

Svetlana A. Borisova, Changsheng Zhang, Haruko Takahashi, Hua Zhang, Alexander W. Wong, Jon S. Thorson, Hung Wen Liu

Research output: Contribution to journalArticlepeer-review

71 Scopus citations

Abstract

(Chemical Equation Presented) Two's Company: DesVII, a glycosyltransferase involved in the biosynthesis of macrolide antibiotics, is unusual in that it requires an additional protein partner, DesVIII, for its full activity. The level of substrate tolerance of the DesVII/DesVIII pair was explored.

Original languageEnglish
Pages (from-to)2748-2753
Number of pages6
JournalAngewandte Chemie - International Edition
Volume45
Issue number17
DOIs
StatePublished - Apr 21 2006

Keywords

  • Antibiotics
  • Biosynthesis
  • Carbohydrates
  • Glycosylation
  • Macrolides

ASJC Scopus subject areas

  • Catalysis
  • General Chemistry

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