Substrate specificity of the macrolide-glycosylating enzyme pair DesVII/DesVIII: Opportunities, limitations, and mechanistic hypotheses

Svetlana A. Borisova; Changsheng Zhang; Haruko Takahashi; Hua Zhang; Alexander W. Wong; Jon S. Thorson; Hung Wen Liu

doi:10.1002/anie.200503195

Substrate specificity of the macrolide-glycosylating enzyme pair DesVII/DesVIII: Opportunities, limitations, and mechanistic hypotheses

Svetlana A. Borisova, Changsheng Zhang, Haruko Takahashi, Hua Zhang, Alexander W. Wong, Jon S. Thorson, Hung Wen Liu

Research output: Contribution to journal › Article › peer-review

71 Scopus citations

Abstract

(Chemical Equation Presented) Two's Company: DesVII, a glycosyltransferase involved in the biosynthesis of macrolide antibiotics, is unusual in that it requires an additional protein partner, DesVIII, for its full activity. The level of substrate tolerance of the DesVII/DesVIII pair was explored.

Original language	English
Pages (from-to)	2748-2753
Number of pages	6
Journal	Angewandte Chemie - International Edition
Volume	45
Issue number	17
DOIs	https://doi.org/10.1002/anie.200503195
State	Published - Apr 21 2006

Keywords

Antibiotics
Biosynthesis
Carbohydrates
Glycosylation
Macrolides

ASJC Scopus subject areas

Catalysis
Chemistry (all)

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10.1002/anie.200503195

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abstract = "(Chemical Equation Presented) Two's Company: DesVII, a glycosyltransferase involved in the biosynthesis of macrolide antibiotics, is unusual in that it requires an additional protein partner, DesVIII, for its full activity. The level of substrate tolerance of the DesVII/DesVIII pair was explored.",

keywords = "Antibiotics, Biosynthesis, Carbohydrates, Glycosylation, Macrolides",

author = "Borisova, {Svetlana A.} and Changsheng Zhang and Haruko Takahashi and Hua Zhang and Wong, {Alexander W.} and Thorson, {Jon S.} and Liu, {Hung Wen}",

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T2 - Opportunities, limitations, and mechanistic hypotheses

AU - Borisova, Svetlana A.

AU - Zhang, Changsheng

AU - Takahashi, Haruko

AU - Zhang, Hua

AU - Wong, Alexander W.

AU - Thorson, Jon S.

AU - Liu, Hung Wen

PY - 2006/4/21

Y1 - 2006/4/21

N2 - (Chemical Equation Presented) Two's Company: DesVII, a glycosyltransferase involved in the biosynthesis of macrolide antibiotics, is unusual in that it requires an additional protein partner, DesVIII, for its full activity. The level of substrate tolerance of the DesVII/DesVIII pair was explored.

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KW - Antibiotics

KW - Biosynthesis

KW - Carbohydrates

KW - Glycosylation

KW - Macrolides

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Substrate specificity of the macrolide-glycosylating enzyme pair DesVII/DesVIII: Opportunities, limitations, and mechanistic hypotheses

Abstract

Keywords

ASJC Scopus subject areas

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