Subtle Pathophysiological Changes in Working Memory-Related Potentials and Intrinsic Theta Power in Community-Dwelling Older Adults With Subjective Cognitive Decline

Zhiwei Zheng, Xiaofeng Zhao, Xiaoyu Cui, Xiaomei Liu, Xinyi Zhu, Yang Jiang, Juan Li

Research output: Contribution to journalArticlepeer-review

2 Scopus citations

Abstract

Background and Objectives: Individuals with subjective cognitive decline (SCD) who perform normally on objective cognitive tests may have an increased risk of pathological cognitive decline and progression to Alzheimer's disease (AD) and related dementia (ADRD). Working memory is widely regarded as an early sign of pathological cognitive decline. We tested the hypothesis that older adults with SCD already exhibit aberrant neurocognitive processing underlying working memory. Research Design and Methods: Electroencephalography (EEG) was recorded during a delayed match-to-sample (DMS) task and an eyes-closed resting condition in cognitively healthy community-dwelling older adults who were assigned to the SCD or Control group. Results: The SCD and Control groups showed comparable performance on the neuropsychological tests and DMS task. The SCD group showed an enhanced right frontal target-related P300 effect during working memory retrieval and higher frontal theta power during rest. Higher theta power was associated with worse working memory performance and greater left frontal nontarget-related positivity across all older adults. Discussion and Implications: Our findings suggest that older people with SCD have subtle pathophysiological changes in working memory-related potentials and intrinsic theta power, which has important implications for predicting risks and early interventions in older adults in the preclinical stage of ADRD.

Original languageEnglish
Article numberigad004
JournalInnovation in Aging
Volume7
Issue number2
DOIs
StatePublished - 2023

Bibliographical note

Publisher Copyright:
© 2023 The Author(s). Published by Oxford University Press on behalf of The Gerontological Society of America.

Keywords

  • Delayed match-to-sample
  • Event-related potentials
  • Resting-state EEG

ASJC Scopus subject areas

  • Health(social science)
  • Health Professions (miscellaneous)
  • Life-span and Life-course Studies

Fingerprint

Dive into the research topics of 'Subtle Pathophysiological Changes in Working Memory-Related Potentials and Intrinsic Theta Power in Community-Dwelling Older Adults With Subjective Cognitive Decline'. Together they form a unique fingerprint.

Cite this