Abstract
Background and Objectives: Individuals with subjective cognitive decline (SCD) who perform normally on objective cognitive tests may have an increased risk of pathological cognitive decline and progression to Alzheimer's disease (AD) and related dementia (ADRD). Working memory is widely regarded as an early sign of pathological cognitive decline. We tested the hypothesis that older adults with SCD already exhibit aberrant neurocognitive processing underlying working memory. Research Design and Methods: Electroencephalography (EEG) was recorded during a delayed match-to-sample (DMS) task and an eyes-closed resting condition in cognitively healthy community-dwelling older adults who were assigned to the SCD or Control group. Results: The SCD and Control groups showed comparable performance on the neuropsychological tests and DMS task. The SCD group showed an enhanced right frontal target-related P300 effect during working memory retrieval and higher frontal theta power during rest. Higher theta power was associated with worse working memory performance and greater left frontal nontarget-related positivity across all older adults. Discussion and Implications: Our findings suggest that older people with SCD have subtle pathophysiological changes in working memory-related potentials and intrinsic theta power, which has important implications for predicting risks and early interventions in older adults in the preclinical stage of ADRD.
| Original language | English |
|---|---|
| Article number | igad004 |
| Journal | Innovation in Aging |
| Volume | 7 |
| Issue number | 2 |
| DOIs | |
| State | Published - 2023 |
Bibliographical note
Publisher Copyright:© 2023 The Author(s). Published by Oxford University Press on behalf of The Gerontological Society of America.
Funding
We would like to thank Professor X. Zhao s laboratory at the University of Tennessee for technical support. This work was supported by the National Key Research and Development Program of China (2020YFC2003000, 2018YFC2000300, 2018YFC2001701, 2016YFC1305900, 2017YFB1401203); the National Natural Science Foundation of China (32271121, 32071079, 31861133011); the Youth Innovation Promotion Association of the Chinese Academy of Sciences (2020089); the Scientific Foundation of Institute of Psychology, Chinese Academy of Sciences (E2CX3715CX); CAS Engineering Laboratory for Psychological Service (KFJ-PTXM-29); and the United States National Institute of Health (R56AG060608-01 to Y. Jiang). This work was supported by the National Key Research and Development Program of China (2020YFC2003000, 2018YFC2000300, 2018YFC2001701, 2016YFC1305900, 2017YFB1401203); the National Natural Science Foundation of China (32271121, 32071079, 31861133011); the Youth Innovation Promotion Association of the Chinese Academy of Sciences (2020089); the Scientific Foundation of Institute of Psychology, Chinese Academy of Sciences (E2CX3715CX); CAS Engineering Laboratory for Psychological Service (KFJ-PTXM-29); and the United States National Institute of Health (R56AG060608-01 to Y. Jiang).
| Funders | Funder number |
|---|---|
| CAS Engineering Laboratory for Psychological Service | KFJ-PTXM-29 |
| National Institutes of Health (NIH) | R56AG060608-01 |
| University of Tennessee | |
| National Natural Science Foundation of China (NSFC) | 32271121, 32071079, 31861133011 |
| Chinese Academy of Sciences | E2CX3715CX |
| Youth Innovation Promotion Association of the Chinese Academy of Sciences | 2020089 |
| National Key Research and Development Program of China | 2020YFC2003000, 2018YFC2000300, 2017YFB1401203, 2016YFC1305900, 2018YFC2001701 |
Keywords
- Delayed match-to-sample
- Event-related potentials
- Resting-state EEG
ASJC Scopus subject areas
- Health(social science)
- Health Professions (miscellaneous)
- Life-span and Life-course Studies