TY - JOUR
T1 - Successful Combined Heart and Kidney Transplantation in Patient With Fabry's Disease
T2 - A Case Report
AU - Rajagopalan, Navin
AU - Dennis, Donna R.
AU - O'Connor, William
N1 - Publisher Copyright:
© 2019 Elsevier Inc.
PY - 2019/11
Y1 - 2019/11
N2 - Fabry's disease is a X-linked hereditary disease that causes the accumulation of glycosphingolipids in tissues and organs, including the kidneys and heart. This can result in both chronic kidney disease and cardiac dysfunction, including arrhythmias and heart failure. We describe a case of a 62-year-old male with Fabry's disease undergoing successful combined heart and kidney transplantation for chronic renal failure and low-output systolic heart failure. The patient has normal cardiac function and normal renal function 7 years after transplantation, while being maintained on enzyme replacement therapy with recombinant human alpha-galactosidase A. Fabry's disease is not a contraindication for organ transplantation, even in patients presenting with both renal failure and heart failure.
AB - Fabry's disease is a X-linked hereditary disease that causes the accumulation of glycosphingolipids in tissues and organs, including the kidneys and heart. This can result in both chronic kidney disease and cardiac dysfunction, including arrhythmias and heart failure. We describe a case of a 62-year-old male with Fabry's disease undergoing successful combined heart and kidney transplantation for chronic renal failure and low-output systolic heart failure. The patient has normal cardiac function and normal renal function 7 years after transplantation, while being maintained on enzyme replacement therapy with recombinant human alpha-galactosidase A. Fabry's disease is not a contraindication for organ transplantation, even in patients presenting with both renal failure and heart failure.
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U2 - 10.1016/j.transproceed.2019.03.032
DO - 10.1016/j.transproceed.2019.03.032
M3 - Article
C2 - 31371217
AN - SCOPUS:85069862229
SN - 0041-1345
VL - 51
SP - 3171
EP - 3173
JO - Transplantation Proceedings
JF - Transplantation Proceedings
IS - 9
ER -
