Sulfonamides as multifunctional agents for Alzheimer's disease

Seema Bag, Rekha Tulsan, Abha Sood, Hyejin Cho, Hana Redjeb, Weihong Zhou, Harry Levine, Béla Török, Marianna Török

Research output: Contribution to journalArticlepeer-review

79 Scopus citations

Abstract

Sulfonamide linker-based inhibitors with extended linear structure were designed and synthesized with the aim of producing multifunctional agents against several processes involved in the pathology of Alzheimer's disease (AD). The potency of the compounds were assessed in the inhibition of Aβ self-assembly (fibril and oligomer formation), in modulating cholinesterase (AChE, BuChE) activity, and scavenging free radicals. Several compounds exhibited promising Aβ self-assembly and cholinesterase inhibition and in parallel, showed good free radical scavenging properties. The investigation of the scaffold described in this study resulted in the identification of three compounds (14, 19 and 26) as promising leads for the further design of multifunctional drug candidates for AD.

Original languageEnglish
Pages (from-to)626-630
Number of pages5
JournalBioorganic and Medicinal Chemistry Letters
Volume25
Issue number3
DOIs
StatePublished - Feb 1 2015

Bibliographical note

Publisher Copyright:
© 2014 Elsevier Ltd. All rights reserved.

Keywords

  • Alzheimer's disease
  • Amyloid-β Cholinesterase inhibition
  • Antioxidant
  • Sulfonamides

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Medicine
  • Molecular Biology
  • Pharmaceutical Science
  • Drug Discovery
  • Clinical Biochemistry
  • Organic Chemistry

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