Sulfonamides as multifunctional agents for Alzheimer's disease

Seema Bag; Rekha Tulsan; Abha Sood; Hyejin Cho; Hana Redjeb; Weihong Zhou; Harry Levine; Béla Török; Marianna Török

doi:10.1016/j.bmcl.2014.12.006

Sulfonamides as multifunctional agents for Alzheimer's disease

Seema Bag, Rekha Tulsan, Abha Sood, Hyejin Cho, Hana Redjeb, Weihong Zhou, Harry Levine, Béla Török, Marianna Török

Molecular and Cellular Biochemistry

Research output: Contribution to journal › Article › peer-review

84 Scopus citations

Abstract

Sulfonamide linker-based inhibitors with extended linear structure were designed and synthesized with the aim of producing multifunctional agents against several processes involved in the pathology of Alzheimer's disease (AD). The potency of the compounds were assessed in the inhibition of Aβ self-assembly (fibril and oligomer formation), in modulating cholinesterase (AChE, BuChE) activity, and scavenging free radicals. Several compounds exhibited promising Aβ self-assembly and cholinesterase inhibition and in parallel, showed good free radical scavenging properties. The investigation of the scaffold described in this study resulted in the identification of three compounds (14, 19 and 26) as promising leads for the further design of multifunctional drug candidates for AD.

Original language	English
Pages (from-to)	626-630
Number of pages	5
Journal	Bioorganic and Medicinal Chemistry Letters
Volume	25
Issue number	3
DOIs	https://doi.org/10.1016/j.bmcl.2014.12.006
State	Published - Feb 1 2015

Bibliographical note

Publisher Copyright:
© 2014 Elsevier Ltd. All rights reserved.

Keywords

Alzheimer's disease
Amyloid-β Cholinesterase inhibition
Antioxidant
Sulfonamides

ASJC Scopus subject areas

Biochemistry
Molecular Medicine
Molecular Biology
Pharmaceutical Science
Drug Discovery
Clinical Biochemistry
Organic Chemistry

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10.1016/j.bmcl.2014.12.006

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abstract = "Sulfonamide linker-based inhibitors with extended linear structure were designed and synthesized with the aim of producing multifunctional agents against several processes involved in the pathology of Alzheimer's disease (AD). The potency of the compounds were assessed in the inhibition of Aβ self-assembly (fibril and oligomer formation), in modulating cholinesterase (AChE, BuChE) activity, and scavenging free radicals. Several compounds exhibited promising Aβ self-assembly and cholinesterase inhibition and in parallel, showed good free radical scavenging properties. The investigation of the scaffold described in this study resulted in the identification of three compounds (14, 19 and 26) as promising leads for the further design of multifunctional drug candidates for AD.",

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AU - Bag, Seema

AU - Tulsan, Rekha

AU - Sood, Abha

AU - Cho, Hyejin

AU - Redjeb, Hana

AU - Zhou, Weihong

AU - Levine, Harry

AU - Török, Béla

AU - Török, Marianna

PY - 2015/2/1

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KW - Antioxidant

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Sulfonamides as multifunctional agents for Alzheimer's disease

Abstract

Bibliographical note

Keywords

ASJC Scopus subject areas

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