[3H]TCP binding sites in Alzheimer's disease

D. T. Monaghan; J. W. Geddes; D. Yao; C. Chung; C. W. Cotman

doi:10.1016/0304-3940(87)90017-6

[³H]TCP binding sites in Alzheimer's disease

D. T. Monaghan, J. W. Geddes, D. Yao, C. Chung, C. W. Cotman

Neuroscience

Research output: Contribution to journal › Article › peer-review

68 Scopus citations

Abstract

Quantitative autoradiography was used to determine the density and distribution of [³H]1-[1-(2-thienyl)-cyclohexyl]piperidine ([³H]TCP) binding sites in human hippocampal tissue sections from control and Alzheimer's disease patients. Some Alzheimer's cases showed no changes in binding site density while other cases showed substantial declines in the CA₁ region. [³H]TCP binding in the CA₁ region from Alzheimer's patients was reduced an average of 40% while the other hippocampal regions were unaffected. It is proposed that the loss of [³H]TCP sites in the hippocampal CA₁ region of certain Alzheimer's cases is associated with the greater cell loss observed in cases of severe Alzheimer's disease.

Original language	English
Pages (from-to)	197-200
Number of pages	4
Journal	Neuroscience Letters
Volume	73
Issue number	2
DOIs	https://doi.org/10.1016/0304-3940(87)90017-6
State	Published - Jan 14 1987

Keywords

Alzheimer's disease
Autoradiography
Excitatory amino acid
Hippocampus
N-methyl-d-aspartate (NMDA)
Phencyclidine

ASJC Scopus subject areas

General Neuroscience

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.1016/0304-3940(87)90017-6

Cite this

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abstract = "Quantitative autoradiography was used to determine the density and distribution of [3H]1-[1-(2-thienyl)-cyclohexyl]piperidine ([3H]TCP) binding sites in human hippocampal tissue sections from control and Alzheimer's disease patients. Some Alzheimer's cases showed no changes in binding site density while other cases showed substantial declines in the CA1 region. [3H]TCP binding in the CA1 region from Alzheimer's patients was reduced an average of 40% while the other hippocampal regions were unaffected. It is proposed that the loss of [3H]TCP sites in the hippocampal CA1 region of certain Alzheimer's cases is associated with the greater cell loss observed in cases of severe Alzheimer's disease.",

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AU - Geddes, J. W.

AU - Yao, D.

AU - Chung, C.

AU - Cotman, C. W.

PY - 1987/1/14

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