Superior intensity and reproducibility of SHU-454, a new right heart contrast agent

Mikel D. Smith, Oi Ling Kwan, H. Joseph Reiser, Anthony N. DeMaria

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52 Scopus citations


Intravenous injection of a variety of fluids has been shown to produce right heart contrast by ultrasound, but the intensity and reproducibility achieved are variable. Thus, a new polysaccharide agent being developed for commercial distribution, SHU-454, was quantitatively compared for intensity and variability with agitated saline solution, indocyanine green, carbon dioxide and hydrogen peroxide. Videodensitometry was used to measure peak and total opacification of the right ventricle after peripheral intravenous contrast administration. One hundred eighty injections were performed in nine closed chest dogs while two-dimensional echograms were re corded. SHU-454 yielded the highest peak (p < 0.001) and total (p < 0.005) intensity values when compared with the standard agents. In addition, SHU-454 yielded the lowest coefficient of variation between injections (p < 0.04) in producing this contrast effect. There were no biologically significant changes in heart rate, blood pressure or arterial blood gases during injection of any of the substances used. A newly developed agent, SHU454, is superior to standard agents in the ability to reliably produce right heart contrast after venous injection in dogs.

Original languageEnglish
Pages (from-to)992-998
Number of pages7
JournalJournal of the American College of Cardiology
Issue number4
StatePublished - 1984

Bibliographical note

Funding Information:
From the Division of Cardiovascular Medicine. University of Kentucky College of Medicine and Veterans Administration Medical Center. Lexington. Kentucky. This study was supported in part by a grant from the American Heart Association. Kentucky Aftiliate. Louisville. Kentucky. Manuscript received August 29.1983; revised manuscript received October 19. 1983. accepted October 29. 1983. Address for reprints: Mikel D. Smith. MD. Division of Cardiology. Department of Medicine. University of Kentucky College of Medicine. 800 Rose Street. MN-670. Lexington. Kentucky 40536-0084.

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine


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