Superoxide dismutases and superoxide reductases

Yuewei Sheng; Isabel A. Abreu; Diane E. Cabelli; Michael J. Maroney; Anne Frances Miller; Miguel Teixeira; Joan Selverstone Valentine

doi:10.1021/cr4005296

Superoxide dismutases and superoxide reductases

Yuewei Sheng, Isabel A. Abreu, Diane E. Cabelli, Michael J. Maroney, Anne Frances Miller, Miguel Teixeira, Joan Selverstone Valentine

Research output: Contribution to journal › Review article › peer-review

788 Scopus citations

Abstract

A scientific review presents information about superoxide dismutases and superoxide reductases. The review reveals that the superoxide reductase (SOR) and three very different types of superoxide dismutase (SOD) enzymes are redox-active metalloenzymes that have evolved entirely independently from one another for the purpose of lowering superoxide concentrations. SODs catalyze the disproportionation of superoxide to give O₂ and H₂O ₂, a reaction requiring one proton per superoxide reacted without external reductant. All of the SOR enzymes contain only iron, while the three types of SODs are the nickel-containing SODs (NiSOD), the iron- or manganese-containing SODs (FeSOD and MnSOD), and the copper- and zinc-containing SODs (CuZnSOD).

Original language	English
Pages (from-to)	3854-3918
Number of pages	65
Journal	Chemical Reviews
Volume	114
Issue number	7
DOIs	https://doi.org/10.1021/cr4005296
State	Published - Apr 9 2014

ASJC Scopus subject areas

General Chemistry

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title = "Superoxide dismutases and superoxide reductases",

abstract = "A scientific review presents information about superoxide dismutases and superoxide reductases. The review reveals that the superoxide reductase (SOR) and three very different types of superoxide dismutase (SOD) enzymes are redox-active metalloenzymes that have evolved entirely independently from one another for the purpose of lowering superoxide concentrations. SODs catalyze the disproportionation of superoxide to give O2 and H2O 2, a reaction requiring one proton per superoxide reacted without external reductant. All of the SOR enzymes contain only iron, while the three types of SODs are the nickel-containing SODs (NiSOD), the iron- or manganese-containing SODs (FeSOD and MnSOD), and the copper- and zinc-containing SODs (CuZnSOD).",

author = "Yuewei Sheng and Abreu, {Isabel A.} and Cabelli, {Diane E.} and Maroney, {Michael J.} and Miller, {Anne Frances} and Miguel Teixeira and Valentine, {Joan Selverstone}",

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doi = "10.1021/cr4005296",

language = "English",

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AU - Sheng, Yuewei

AU - Abreu, Isabel A.

AU - Cabelli, Diane E.

AU - Maroney, Michael J.

AU - Miller, Anne Frances

AU - Teixeira, Miguel

AU - Valentine, Joan Selverstone

PY - 2014/4/9

Y1 - 2014/4/9

N2 - A scientific review presents information about superoxide dismutases and superoxide reductases. The review reveals that the superoxide reductase (SOR) and three very different types of superoxide dismutase (SOD) enzymes are redox-active metalloenzymes that have evolved entirely independently from one another for the purpose of lowering superoxide concentrations. SODs catalyze the disproportionation of superoxide to give O2 and H2O 2, a reaction requiring one proton per superoxide reacted without external reductant. All of the SOR enzymes contain only iron, while the three types of SODs are the nickel-containing SODs (NiSOD), the iron- or manganese-containing SODs (FeSOD and MnSOD), and the copper- and zinc-containing SODs (CuZnSOD).

AB - A scientific review presents information about superoxide dismutases and superoxide reductases. The review reveals that the superoxide reductase (SOR) and three very different types of superoxide dismutase (SOD) enzymes are redox-active metalloenzymes that have evolved entirely independently from one another for the purpose of lowering superoxide concentrations. SODs catalyze the disproportionation of superoxide to give O2 and H2O 2, a reaction requiring one proton per superoxide reacted without external reductant. All of the SOR enzymes contain only iron, while the three types of SODs are the nickel-containing SODs (NiSOD), the iron- or manganese-containing SODs (FeSOD and MnSOD), and the copper- and zinc-containing SODs (CuZnSOD).

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Superoxide dismutases and superoxide reductases

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