Superoxide dismutases and superoxide reductases

Yuewei Sheng; Isabel A. Abreu; Diane E. Cabelli; Michael J. Maroney; Anne Frances Miller; Miguel Teixeira; Joan Selverstone Valentine

doi:10.1021/cr4005296

Superoxide dismutases and superoxide reductases

Yuewei Sheng, Isabel A. Abreu, Diane E. Cabelli, Michael J. Maroney, Anne Frances Miller, Miguel Teixeira, Joan Selverstone Valentine

Research output: Contribution to journal › Review article › peer-review

895 Scopus citations

Abstract

A scientific review presents information about superoxide dismutases and superoxide reductases. The review reveals that the superoxide reductase (SOR) and three very different types of superoxide dismutase (SOD) enzymes are redox-active metalloenzymes that have evolved entirely independently from one another for the purpose of lowering superoxide concentrations. SODs catalyze the disproportionation of superoxide to give O₂ and H₂O ₂, a reaction requiring one proton per superoxide reacted without external reductant. All of the SOR enzymes contain only iron, while the three types of SODs are the nickel-containing SODs (NiSOD), the iron- or manganese-containing SODs (FeSOD and MnSOD), and the copper- and zinc-containing SODs (CuZnSOD).

Original language	English
Pages (from-to)	3854-3918
Number of pages	65
Journal	Chemical Reviews
Volume	114
Issue number	7
DOIs	https://doi.org/10.1021/cr4005296
State	Published - Apr 9 2014

Funding

Funders	Funder number
National Institute of General Medical Sciences DP2GM119177 Sophie Dumont National Institute of General Medical Sciences	R01GM028222, R01GM055210, R01GM069696, R01GM085302
Fundação para a Ciência e Tecnologia I.P.	SFRH/BPD/78314/2011
National Science Foundation Arctic Social Science Program	1111462
Institute of Neurological Disorders and Stroke National Advisory Neurological Disorders and Stroke Council	P01NS049134
UK Industrial Decarbonization Research and Innovation Centre	43784

ASJC Scopus subject areas

General Chemistry

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title = "Superoxide dismutases and superoxide reductases",

abstract = "A scientific review presents information about superoxide dismutases and superoxide reductases. The review reveals that the superoxide reductase (SOR) and three very different types of superoxide dismutase (SOD) enzymes are redox-active metalloenzymes that have evolved entirely independently from one another for the purpose of lowering superoxide concentrations. SODs catalyze the disproportionation of superoxide to give O2 and H2O 2, a reaction requiring one proton per superoxide reacted without external reductant. All of the SOR enzymes contain only iron, while the three types of SODs are the nickel-containing SODs (NiSOD), the iron- or manganese-containing SODs (FeSOD and MnSOD), and the copper- and zinc-containing SODs (CuZnSOD).",

author = "Yuewei Sheng and Abreu, \{Isabel A.\} and Cabelli, \{Diane E.\} and Maroney, \{Michael J.\} and Miller, \{Anne Frances\} and Miguel Teixeira and Valentine, \{Joan Selverstone\}",

year = "2014",

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doi = "10.1021/cr4005296",

language = "English",

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T1 - Superoxide dismutases and superoxide reductases

AU - Sheng, Yuewei

AU - Abreu, Isabel A.

AU - Cabelli, Diane E.

AU - Maroney, Michael J.

AU - Miller, Anne Frances

AU - Teixeira, Miguel

AU - Valentine, Joan Selverstone

PY - 2014/4/9

Y1 - 2014/4/9

N2 - A scientific review presents information about superoxide dismutases and superoxide reductases. The review reveals that the superoxide reductase (SOR) and three very different types of superoxide dismutase (SOD) enzymes are redox-active metalloenzymes that have evolved entirely independently from one another for the purpose of lowering superoxide concentrations. SODs catalyze the disproportionation of superoxide to give O2 and H2O 2, a reaction requiring one proton per superoxide reacted without external reductant. All of the SOR enzymes contain only iron, while the three types of SODs are the nickel-containing SODs (NiSOD), the iron- or manganese-containing SODs (FeSOD and MnSOD), and the copper- and zinc-containing SODs (CuZnSOD).

AB - A scientific review presents information about superoxide dismutases and superoxide reductases. The review reveals that the superoxide reductase (SOR) and three very different types of superoxide dismutase (SOD) enzymes are redox-active metalloenzymes that have evolved entirely independently from one another for the purpose of lowering superoxide concentrations. SODs catalyze the disproportionation of superoxide to give O2 and H2O 2, a reaction requiring one proton per superoxide reacted without external reductant. All of the SOR enzymes contain only iron, while the three types of SODs are the nickel-containing SODs (NiSOD), the iron- or manganese-containing SODs (FeSOD and MnSOD), and the copper- and zinc-containing SODs (CuZnSOD).

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Superoxide dismutases and superoxide reductases

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