Suppressing iron oxide nanoparticle toxicity by vascular targeted antioxidant polymer nanoparticles

David B. Cochran, Paritosh P. Wattamwar, Robert Wydra, J. Zach Hilt, Kimberly W. Anderson, Richard E. Eitel, Thomas D. Dziubla

Research output: Contribution to journalArticlepeer-review

58 Scopus citations


The biomedical use of superparamagnetic iron oxide nanoparticles has been of continued interest in the literature and clinic. Their ability to be used as contrast agents for imaging and/or responsive agents for remote actuation makes them exciting materials for a wide range of clinical applications. Recently, however, concern has arisen regarding the potential health effects of these particles. Iron oxide toxicity has been demonstrated in invivo and invitro models, with oxidative stress being implicated as playing a key role in this pathology. One of the key cell types implicated in this injury is the vascular endothelial cells. Here, we report on the development of a targeted polymeric antioxidant, poly(trolox ester), nanoparticle that can suppress oxidative damage. As the polymer undergoes enzymatic hydrolysis, active trolox is locally released, providing a long term protection against pro-oxidant agents. In this work, poly(trolox) nanoparticles are targeted to platelet endothelial cell adhesion molecules (PECAM-1), which are able to bind to and internalize in endothelial cells and provide localized protection against the cytotoxicity caused by iron oxide nanoparticles. These results indicate the potential of using poly(trolox ester) as a means of mitigating iron oxide toxicity, potentially expanding the clinical use and relevance of these exciting systems.

Original languageEnglish
Pages (from-to)9615-9622
Number of pages8
Issue number37
StatePublished - Dec 2013

Bibliographical note

Funding Information:
Funding for this study was provided by the Office of Naval Research Department of Defense Experimental Program to Stimulate Competitive Research (ONR DEPSCoR) and the NSF Integrative Graduate Education and Research Traineeship (IGERT 0653710) Bioactive interfaces and Devices program.


  • Adhesion molecule
  • Antioxidant
  • Endothelial cell
  • Nanoparticle
  • Oxidation

ASJC Scopus subject areas

  • Bioengineering
  • Ceramics and Composites
  • Biophysics
  • Biomaterials
  • Mechanics of Materials


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