Suppression of corticosterone synthesis alters the behavior of hippocampally lesioned rats

Jeanne P. Ryan, Joe E. Springer, John H. Hannigan, Robert L. Isaacson

Research output: Contribution to journalArticlepeer-review

7 Scopus citations

Abstract

The suppression of corticosterone synthesis with metyrapone (25 mg/kg) reduced the hyperactivity and altered the exploratory activity of hippocampally lesioned animals (HPC) in the open field to the level of cortical and sham controls (Experiment 1). In a second experiment, corticosterone (600 μg/kg) pretreatment 2 h, but not 1 h, before metyrapone partially restored the hyperactivity of HPC animals that had been decreased by the corticosteroid-suppressant drug. Alterations in exploratory behavior induced by metyrapone were also prevented by corticosterone pretreatment. The results suggest that the suppression of corticosterone in hippocampally lesioned animals produces a normalization of behavior that can be prevented by pretreatment with corticosterone.

Original languageEnglish
Pages (from-to)47-59
Number of pages13
JournalBehavioral and Neural Biology
Volume44
Issue number1
DOIs
StatePublished - Jul 1985

ASJC Scopus subject areas

  • Physiology

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