Abstract
A mouse fibrosarcoma cell line (FSa-II), which exhibits low endogenous levels of manganese superoxide dismutase, was transfected with a human manganese superoxide dismutase complementary DNA Fifty clones were screened for manganese superoxide dismutase activity by the superoxide dismutase activity gel assay. Activity of the positive clones was measured by the nitro blue tetrazolium-reduction assay in the presence of cyanide. Three cell lines exhibiting a range of activity were chosen to be transplanted into syngeneic mice. The results indicated that the metastasis rate for all transfected cells was significantly less than that of control cells.
| Original language | English |
|---|---|
| Pages (from-to) | 4261-4265 |
| Number of pages | 5 |
| Journal | Cancer Research |
| Volume | 54 |
| Issue number | 16 |
| State | Published - Aug 1994 |
ASJC Scopus subject areas
- Oncology
- Cancer Research
