Suppression of growth and transformation and induction of apoptosis by EGR-1

Chaoting Liu; Vivek M. Rangnekar; Eileen Adamson; Dan Mercola

Suppression of growth and transformation and induction of apoptosis by EGR-1

Chaoting Liu, Vivek M. Rangnekar, Eileen Adamson, Dan Mercola

Research output: Contribution to journal › Article › peer-review

216 Scopus citations

Abstract

Although cloned as an "immediate-early gene," recent studies show that EGR-1 functions in growth regulation and suppression of transformation by transactivation of the transforming growth factor β-1 (TGF-β1) gene and cooperation with Sp1, Jun-B, p21^WAFl/Cip1, and stimulates apoptosis by transactivation of the p53 gene.

Original language	English
Pages (from-to)	3-28
Number of pages	26
Journal	Cancer Gene Therapy
Volume	5
Issue number	1
State	Published - 1998

Keywords

Cancer
EGR-1
Sp1
Transformation
Transforming growth factor β-1
WT1

ASJC Scopus subject areas

Molecular Medicine
Molecular Biology
Cancer Research

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Cite this

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title = "Suppression of growth and transformation and induction of apoptosis by EGR-1",

abstract = "Although cloned as an {"}immediate-early gene,{"} recent studies show that EGR-1 functions in growth regulation and suppression of transformation by transactivation of the transforming growth factor β-1 (TGF-β1) gene and cooperation with Sp1, Jun-B, p21WAFl/Cip1, and stimulates apoptosis by transactivation of the p53 gene.",

keywords = "Cancer, EGR-1, Sp1, Transformation, Transforming growth factor β-1, WT1",

author = "Chaoting Liu and Rangnekar, {Vivek M.} and Eileen Adamson and Dan Mercola",

year = "1998",

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T1 - Suppression of growth and transformation and induction of apoptosis by EGR-1

AU - Liu, Chaoting

AU - Rangnekar, Vivek M.

AU - Adamson, Eileen

AU - Mercola, Dan

PY - 1998

Y1 - 1998

N2 - Although cloned as an "immediate-early gene," recent studies show that EGR-1 functions in growth regulation and suppression of transformation by transactivation of the transforming growth factor β-1 (TGF-β1) gene and cooperation with Sp1, Jun-B, p21WAFl/Cip1, and stimulates apoptosis by transactivation of the p53 gene.

AB - Although cloned as an "immediate-early gene," recent studies show that EGR-1 functions in growth regulation and suppression of transformation by transactivation of the transforming growth factor β-1 (TGF-β1) gene and cooperation with Sp1, Jun-B, p21WAFl/Cip1, and stimulates apoptosis by transactivation of the p53 gene.

KW - Cancer

KW - EGR-1

KW - Sp1

KW - Transformation

KW - Transforming growth factor β-1

KW - WT1

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UR - http://www.scopus.com/inward/citedby.url?scp=0031602586&partnerID=8YFLogxK

M3 - Article

C2 - 9476963

AN - SCOPUS:0031602586

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ER -

Suppression of growth and transformation and induction of apoptosis by EGR-1

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

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