Suppression of growth and transformation and induction of apoptosis by EGR-1

Chaoting Liu, Vivek M. Rangnekar, Eileen Adamson, Dan Mercola

Research output: Contribution to journalArticlepeer-review

219 Scopus citations

Abstract

Although cloned as an "immediate-early gene," recent studies show that EGR-1 functions in growth regulation and suppression of transformation by transactivation of the transforming growth factor β-1 (TGF-β1) gene and cooperation with Sp1, Jun-B, p21WAFl/Cip1, and stimulates apoptosis by transactivation of the p53 gene.

Original languageEnglish
Pages (from-to)3-28
Number of pages26
JournalCancer Gene Therapy
Volume5
Issue number1
StatePublished - 1998

Funding

FundersFunder number
National Childhood Cancer Registry – National Cancer InstituteR01CA063783

    Keywords

    • Cancer
    • EGR-1
    • Sp1
    • Transformation
    • Transforming growth factor β-1
    • WT1

    ASJC Scopus subject areas

    • Molecular Medicine
    • Molecular Biology
    • Cancer Research

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