Abstract
Although cloned as an "immediate-early gene," recent studies show that EGR-1 functions in growth regulation and suppression of transformation by transactivation of the transforming growth factor β-1 (TGF-β1) gene and cooperation with Sp1, Jun-B, p21WAFl/Cip1, and stimulates apoptosis by transactivation of the p53 gene.
Original language | English |
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Pages (from-to) | 3-28 |
Number of pages | 26 |
Journal | Cancer Gene Therapy |
Volume | 5 |
Issue number | 1 |
State | Published - 1998 |
Funding
Funders | Funder number |
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National Childhood Cancer Registry – National Cancer Institute | R01CA063783 |
Keywords
- Cancer
- EGR-1
- Sp1
- Transformation
- Transforming growth factor β-1
- WT1
ASJC Scopus subject areas
- Molecular Medicine
- Molecular Biology
- Cancer Research