TY - JOUR
T1 - Suppression of radiation‐induced neoplastic transformation by overexpression of mitochondrial superoxide dismutase
AU - St. Clair, Daret K.
AU - Steven Wan, X.
AU - Oberley, Terry D.
AU - Muse, Kenneth E.
AU - St. Clair, William H.
PY - 1992
Y1 - 1992
N2 - Manganese superoxide dismutase (MnSOD) scavenges toxic superoxide radicals produced in the mitochondria. Transfection of the human MnSOD gene into mouse C3H 10T1/2 cells resulted in production of active MnSOD, which was properly transported into mitochondria. Overexpression of MnSOD protected cells from radiation‐, but not chemically‐induced neoplastic transformation. This finding demonstrates that oxidative stress that occurs in the mitochondria plays an important role in the development of neoplastic transformation. © 1992 Wiley‐Liss, Inc.
AB - Manganese superoxide dismutase (MnSOD) scavenges toxic superoxide radicals produced in the mitochondria. Transfection of the human MnSOD gene into mouse C3H 10T1/2 cells resulted in production of active MnSOD, which was properly transported into mitochondria. Overexpression of MnSOD protected cells from radiation‐, but not chemically‐induced neoplastic transformation. This finding demonstrates that oxidative stress that occurs in the mitochondria plays an important role in the development of neoplastic transformation. © 1992 Wiley‐Liss, Inc.
KW - Mitochondria
KW - ionizing radiation
KW - neoplastic transformation
KW - superoxide dismutase
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U2 - 10.1002/mc.2940060404
DO - 10.1002/mc.2940060404
M3 - Article
C2 - 1485915
AN - SCOPUS:0027093827
SN - 0899-1987
VL - 6
SP - 238
EP - 242
JO - Molecular Carcinogenesis
JF - Molecular Carcinogenesis
IS - 4
ER -