Suppression of radiation‐induced neoplastic transformation by overexpression of mitochondrial superoxide dismutase

Daret K. St. Clair, X. Steven Wan, Terry D. Oberley, Kenneth E. Muse, William H. St. Clair

Research output: Contribution to journalArticlepeer-review

75 Scopus citations

Abstract

Manganese superoxide dismutase (MnSOD) scavenges toxic superoxide radicals produced in the mitochondria. Transfection of the human MnSOD gene into mouse C3H 10T1/2 cells resulted in production of active MnSOD, which was properly transported into mitochondria. Overexpression of MnSOD protected cells from radiation‐, but not chemically‐induced neoplastic transformation. This finding demonstrates that oxidative stress that occurs in the mitochondria plays an important role in the development of neoplastic transformation. © 1992 Wiley‐Liss, Inc.

Original languageEnglish
Pages (from-to)238-242
Number of pages5
JournalMolecular Carcinogenesis
Volume6
Issue number4
DOIs
StatePublished - 1992

Keywords

  • Mitochondria
  • ionizing radiation
  • neoplastic transformation
  • superoxide dismutase

ASJC Scopus subject areas

  • Molecular Biology
  • Cancer Research

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