Supranigral injection of neuregulin1-β induces striatal dopamine overflow

David M. Yurek, Lixin Zhang, Anita Fletcher-Turner, Kim B. Seroogy

Research output: Contribution to journalArticlepeer-review

40 Scopus citations


Previous studies have provided anatomical evidence that the functional neuregulin receptor, ErbB4, is present within the ventral midbrain where it is co-localized to dopamine neurons of the substantia nigra and ventral tegmental area. In this study, we provide evidence that neuregulin1-β (a.k.a. heregulin1-β), a neuregulin-1 gene isoform that preferentially binds to and activates the ErbB4 receptor, evokes an almost immediate overflow of striatal dopamine when injected into a region just dorsal to the ipsilateral substantia nigra. These data are indicative that neuregulins can modulate the activity of mesostriatal dopaminergic neurons.

Original languageEnglish
Pages (from-to)116-119
Number of pages4
JournalBrain Research
Issue number1
StatePublished - Nov 26 2004

Bibliographical note

Funding Information:
This research was supported by DAMD17-01-1-0766 (DOD), DAMD17-02-1-0174 (DOD) and NS39128 (NIH).


  • ErbB4
  • Microdialysis
  • Nigrostriatal pathway
  • Rodent

ASJC Scopus subject areas

  • Neuroscience (all)
  • Molecular Biology
  • Clinical Neurology
  • Developmental Biology


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