Previous studies have provided anatomical evidence that the functional neuregulin receptor, ErbB4, is present within the ventral midbrain where it is co-localized to dopamine neurons of the substantia nigra and ventral tegmental area. In this study, we provide evidence that neuregulin1-β (a.k.a. heregulin1-β), a neuregulin-1 gene isoform that preferentially binds to and activates the ErbB4 receptor, evokes an almost immediate overflow of striatal dopamine when injected into a region just dorsal to the ipsilateral substantia nigra. These data are indicative that neuregulins can modulate the activity of mesostriatal dopaminergic neurons.
|Number of pages||4|
|State||Published - Nov 26 2004|
Bibliographical noteFunding Information:
This research was supported by DAMD17-01-1-0766 (DOD), DAMD17-02-1-0174 (DOD) and NS39128 (NIH).
- Nigrostriatal pathway
ASJC Scopus subject areas
- Neuroscience (all)
- Molecular Biology
- Clinical Neurology
- Developmental Biology