Supranigral injection of neuregulin1-β induces striatal dopamine overflow

David M. Yurek; Lixin Zhang; Anita Fletcher-Turner; Kim B. Seroogy

doi:10.1016/j.brainres.2004.08.066

Supranigral injection of neuregulin1-β induces striatal dopamine overflow

David M. Yurek, Lixin Zhang, Anita Fletcher-Turner, Kim B. Seroogy

Research output: Contribution to journal › Article › peer-review

40 Scopus citations

Abstract

Previous studies have provided anatomical evidence that the functional neuregulin receptor, ErbB4, is present within the ventral midbrain where it is co-localized to dopamine neurons of the substantia nigra and ventral tegmental area. In this study, we provide evidence that neuregulin1-β (a.k.a. heregulin1-β), a neuregulin-1 gene isoform that preferentially binds to and activates the ErbB4 receptor, evokes an almost immediate overflow of striatal dopamine when injected into a region just dorsal to the ipsilateral substantia nigra. These data are indicative that neuregulins can modulate the activity of mesostriatal dopaminergic neurons.

Original language	English
Pages (from-to)	116-119
Number of pages	4
Journal	Brain Research
Volume	1028
Issue number	1
DOIs	https://doi.org/10.1016/j.brainres.2004.08.066
State	Published - Nov 26 2004

Bibliographical note

Funding Information:
This research was supported by DAMD17-01-1-0766 (DOD), DAMD17-02-1-0174 (DOD) and NS39128 (NIH).

Keywords

ErbB4
Microdialysis
Nigrostriatal pathway
Rodent

ASJC Scopus subject areas

Neuroscience (all)
Molecular Biology
Clinical Neurology
Developmental Biology

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10.1016/j.brainres.2004.08.066

Cite this

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title = "Supranigral injection of neuregulin1-β induces striatal dopamine overflow",

abstract = "Previous studies have provided anatomical evidence that the functional neuregulin receptor, ErbB4, is present within the ventral midbrain where it is co-localized to dopamine neurons of the substantia nigra and ventral tegmental area. In this study, we provide evidence that neuregulin1-β (a.k.a. heregulin1-β), a neuregulin-1 gene isoform that preferentially binds to and activates the ErbB4 receptor, evokes an almost immediate overflow of striatal dopamine when injected into a region just dorsal to the ipsilateral substantia nigra. These data are indicative that neuregulins can modulate the activity of mesostriatal dopaminergic neurons.",

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author = "Yurek, {David M.} and Lixin Zhang and Anita Fletcher-Turner and Seroogy, {Kim B.}",

note = "Funding Information: This research was supported by DAMD17-01-1-0766 (DOD), DAMD17-02-1-0174 (DOD) and NS39128 (NIH).",

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AU - Fletcher-Turner, Anita

AU - Seroogy, Kim B.

N1 - Funding Information: This research was supported by DAMD17-01-1-0766 (DOD), DAMD17-02-1-0174 (DOD) and NS39128 (NIH).

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AB - Previous studies have provided anatomical evidence that the functional neuregulin receptor, ErbB4, is present within the ventral midbrain where it is co-localized to dopamine neurons of the substantia nigra and ventral tegmental area. In this study, we provide evidence that neuregulin1-β (a.k.a. heregulin1-β), a neuregulin-1 gene isoform that preferentially binds to and activates the ErbB4 receptor, evokes an almost immediate overflow of striatal dopamine when injected into a region just dorsal to the ipsilateral substantia nigra. These data are indicative that neuregulins can modulate the activity of mesostriatal dopaminergic neurons.

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Supranigral injection of neuregulin1-β induces striatal dopamine overflow

Abstract

Bibliographical note

Keywords

ASJC Scopus subject areas

Access to Document

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