Surprising Synergy between Cerebrovascular and Lewy Body Disease in Parkinsonism

Research output: Contribution to journalReview articlepeer-review


Parkinsonism is a common and heterogeneous clinical syndrome with symptoms that include rigidity, bradykinesia, tremor, and autonomic dysfunction. The classic substrate of Parkinsonism is Lewy body pathology (LBP), identified by the presence of α-synuclein inclusion bodies. However, non-LBP pathologies may also be associated with Parkinsonism. In this issue of Neurology®, Agrawal et al.1 publish a study that confirms the association between Parkinsonism and LBP and also provide strong indication of the importance of cerebrovascular diseases (CVDs) as an underappreciated driver of Parkinsonism in older community-dwelling persons.

Original languageEnglish
Pages (from-to)290-292
Number of pages3
Issue number7
StatePublished - Aug 15 2023

Bibliographical note

Publisher Copyright:
© 2023 American Academy of Neurology.

ASJC Scopus subject areas

  • Clinical Neurology


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