TY - JOUR
T1 - Surprising Synergy between Cerebrovascular and Lewy Body Disease in Parkinsonism
AU - Nelson, Peter T.
AU - Jicha, Gregory A.
N1 - Publisher Copyright:
© 2023 American Academy of Neurology.
PY - 2023/8/15
Y1 - 2023/8/15
N2 - Parkinsonism is a common and heterogeneous clinical syndrome with symptoms that include rigidity, bradykinesia, tremor, and autonomic dysfunction. The classic substrate of Parkinsonism is Lewy body pathology (LBP), identified by the presence of α-synuclein inclusion bodies. However, non-LBP pathologies may also be associated with Parkinsonism. In this issue of Neurology®, Agrawal et al.1 publish a study that confirms the association between Parkinsonism and LBP and also provide strong indication of the importance of cerebrovascular diseases (CVDs) as an underappreciated driver of Parkinsonism in older community-dwelling persons.
AB - Parkinsonism is a common and heterogeneous clinical syndrome with symptoms that include rigidity, bradykinesia, tremor, and autonomic dysfunction. The classic substrate of Parkinsonism is Lewy body pathology (LBP), identified by the presence of α-synuclein inclusion bodies. However, non-LBP pathologies may also be associated with Parkinsonism. In this issue of Neurology®, Agrawal et al.1 publish a study that confirms the association between Parkinsonism and LBP and also provide strong indication of the importance of cerebrovascular diseases (CVDs) as an underappreciated driver of Parkinsonism in older community-dwelling persons.
UR - http://www.scopus.com/inward/record.url?scp=85168222520&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85168222520&partnerID=8YFLogxK
U2 - 10.1212/WNL.0000000000207572
DO - 10.1212/WNL.0000000000207572
M3 - Review article
C2 - 37344229
AN - SCOPUS:85168222520
SN - 0028-3878
VL - 101
SP - 290
EP - 292
JO - Neurology
JF - Neurology
IS - 7
ER -