'Sweetening' natural products via glycorandomization

Byron R. Griffith; Joseph M. Langenhan; Jon S. Thorson

doi:10.1016/j.copbio.2005.10.002

'Sweetening' natural products via glycorandomization

Byron R. Griffith, Joseph M. Langenhan, Jon S. Thorson

Research output: Contribution to journal › Review article › peer-review

147 Scopus citations

Abstract

In an effort to explore the contribution of the sugar constituents of pharmaceutically relevant glycosylated natural products, chemists have developed glycosylation methods for the generation of 'glycorandomized' libraries. Each member of these libraries is uniquely differentiated by an attached carbohydrate. Recently, two complementary glycorandomization strategies have emerged: chemoenzymatic glycorandomization, a biocatalytic approach dependent upon the substrate promiscuity of enzymes to activate and attach sugars to natural products, and neoglycorandomization, an efficient one-step chemical sugar ligation reaction that does not require prior sugar protection or activation. These strategies are likely to have a significant impact on fundamental glycoscience and drug discovery.

Original language	English
Pages (from-to)	622-630
Number of pages	9
Journal	Current Opinion in Biotechnology
Volume	16
Issue number	6
DOIs	https://doi.org/10.1016/j.copbio.2005.10.002
State	Published - Dec 2005

Bibliographical note

Funding Information:
This contribution was supported in part by the National Institutes of Health grants AI52218, CA84374 and GM70637, and a NCDDG grant from the National Cancer Institute (U19 CA113297). JML is a National Institutes of Health postdoctoral fellow (AI56652), BRG is a postdoctoral fellow of the American Cancer Society (PF-05-016-01-CDD) and JST is a HI Romnes fellow.

ASJC Scopus subject areas

Biotechnology
Bioengineering
Biomedical Engineering

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10.1016/j.copbio.2005.10.002

Cite this

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title = "'Sweetening' natural products via glycorandomization",

abstract = "In an effort to explore the contribution of the sugar constituents of pharmaceutically relevant glycosylated natural products, chemists have developed glycosylation methods for the generation of 'glycorandomized' libraries. Each member of these libraries is uniquely differentiated by an attached carbohydrate. Recently, two complementary glycorandomization strategies have emerged: chemoenzymatic glycorandomization, a biocatalytic approach dependent upon the substrate promiscuity of enzymes to activate and attach sugars to natural products, and neoglycorandomization, an efficient one-step chemical sugar ligation reaction that does not require prior sugar protection or activation. These strategies are likely to have a significant impact on fundamental glycoscience and drug discovery.",

author = "Griffith, {Byron R.} and Langenhan, {Joseph M.} and Thorson, {Jon S.}",

note = "Funding Information: This contribution was supported in part by the National Institutes of Health grants AI52218, CA84374 and GM70637, and a NCDDG grant from the National Cancer Institute (U19 CA113297). JML is a National Institutes of Health postdoctoral fellow (AI56652), BRG is a postdoctoral fellow of the American Cancer Society (PF-05-016-01-CDD) and JST is a HI Romnes fellow. ",

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AU - Langenhan, Joseph M.

AU - Thorson, Jon S.

N1 - Funding Information: This contribution was supported in part by the National Institutes of Health grants AI52218, CA84374 and GM70637, and a NCDDG grant from the National Cancer Institute (U19 CA113297). JML is a National Institutes of Health postdoctoral fellow (AI56652), BRG is a postdoctoral fellow of the American Cancer Society (PF-05-016-01-CDD) and JST is a HI Romnes fellow.

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AB - In an effort to explore the contribution of the sugar constituents of pharmaceutically relevant glycosylated natural products, chemists have developed glycosylation methods for the generation of 'glycorandomized' libraries. Each member of these libraries is uniquely differentiated by an attached carbohydrate. Recently, two complementary glycorandomization strategies have emerged: chemoenzymatic glycorandomization, a biocatalytic approach dependent upon the substrate promiscuity of enzymes to activate and attach sugars to natural products, and neoglycorandomization, an efficient one-step chemical sugar ligation reaction that does not require prior sugar protection or activation. These strategies are likely to have a significant impact on fundamental glycoscience and drug discovery.

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JO - Current Opinion in Biotechnology

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'Sweetening' natural products via glycorandomization

Abstract

Bibliographical note

ASJC Scopus subject areas

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