TY - JOUR
T1 - Synaptic plasticity mediating cocaine relapse requires matrix metalloproteinases
AU - Smith, Alexander C.W.
AU - Kupchik, Yonatan M.
AU - Scofield, Michael D.
AU - Gipson, Cassandra D.
AU - Wiggins, Armina
AU - Thomas, Charles A.
AU - Kalivas, Peter W.
N1 - Publisher Copyright:
© 2014 Nature America, Inc. All rights reserved.
PY - 2014/1/1
Y1 - 2014/1/1
N2 - Relapse to cocaine use necessitates remodeling excitatory synapses in the nucleus accumbens and synaptic reorganization requires matrix metalloproteinase (MMP) degradation of the extracellular matrix proteins. We found enduring increases in MMP-2 activity in rats after withdrawal from self-administered cocaine and transient increases in MMP-9 during cue-induced cocaine relapse. Cue-induced heroin and nicotine relapse increased MMP activity, and increased MMP activity was required for both cocaine relapse and relapse-associated synaptic plasticity.
AB - Relapse to cocaine use necessitates remodeling excitatory synapses in the nucleus accumbens and synaptic reorganization requires matrix metalloproteinase (MMP) degradation of the extracellular matrix proteins. We found enduring increases in MMP-2 activity in rats after withdrawal from self-administered cocaine and transient increases in MMP-9 during cue-induced cocaine relapse. Cue-induced heroin and nicotine relapse increased MMP activity, and increased MMP activity was required for both cocaine relapse and relapse-associated synaptic plasticity.
UR - http://www.scopus.com/inward/record.url?scp=84925226691&partnerID=8YFLogxK
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U2 - 10.1038/nn.3846
DO - 10.1038/nn.3846
M3 - Article
C2 - 25326689
AN - SCOPUS:84925226691
SN - 1097-6256
VL - 17
SP - 1655
EP - 1657
JO - Nature Neuroscience
JF - Nature Neuroscience
IS - 12
ER -