Synergistic effects in gene delivery - A structure-activity approach to the optimisation of hybrid dendritic-lipidic transfection agents

Simon P. Jones; Nathan P. Gabrielson; Daniel W. Pack; David K. Smith

doi:10.1039/b811852c

Synergistic effects in gene delivery - A structure-activity approach to the optimisation of hybrid dendritic-lipidic transfection agents

Simon P. Jones, Nathan P. Gabrielson, Daniel W. Pack, David K. Smith

Research output: Contribution to journal › Article › peer-review

66 Scopus citations

Abstract

Novel gene delivery agents based on combining cholesterol units with spermine-functionalised dendrons exhibit enhanced transfection ability-we report significant synergistic effects in mixed (hybrid) systems which combine aspects of both main classes of synthetic vectors, i.e., cationic polymers and lipids.

Original language	English
Pages (from-to)	4700-4702
Number of pages	3
Journal	Chemical Communications
Issue number	39
DOIs	https://doi.org/10.1039/b811852c
State	Published - 2008

ASJC Scopus subject areas

Catalysis
Electronic, Optical and Magnetic Materials
Ceramics and Composites
General Chemistry
Surfaces, Coatings and Films
Metals and Alloys
Materials Chemistry

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10.1039/b811852c

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title = "Synergistic effects in gene delivery - A structure-activity approach to the optimisation of hybrid dendritic-lipidic transfection agents",

abstract = "Novel gene delivery agents based on combining cholesterol units with spermine-functionalised dendrons exhibit enhanced transfection ability-we report significant synergistic effects in mixed (hybrid) systems which combine aspects of both main classes of synthetic vectors, i.e., cationic polymers and lipids.",

author = "Jones, {Simon P.} and Gabrielson, {Nathan P.} and Pack, {Daniel W.} and Smith, {David K.}",

year = "2008",

doi = "10.1039/b811852c",

language = "English",

pages = "4700--4702",

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AU - Jones, Simon P.

AU - Gabrielson, Nathan P.

AU - Pack, Daniel W.

AU - Smith, David K.

PY - 2008

Y1 - 2008

N2 - Novel gene delivery agents based on combining cholesterol units with spermine-functionalised dendrons exhibit enhanced transfection ability-we report significant synergistic effects in mixed (hybrid) systems which combine aspects of both main classes of synthetic vectors, i.e., cationic polymers and lipids.

AB - Novel gene delivery agents based on combining cholesterol units with spermine-functionalised dendrons exhibit enhanced transfection ability-we report significant synergistic effects in mixed (hybrid) systems which combine aspects of both main classes of synthetic vectors, i.e., cationic polymers and lipids.

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U2 - 10.1039/b811852c

DO - 10.1039/b811852c

M3 - Article

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SN - 1359-7345

SP - 4700

EP - 4702

JO - Chemical Communications

JF - Chemical Communications

IS - 39

ER -

Synergistic effects in gene delivery - A structure-activity approach to the optimisation of hybrid dendritic-lipidic transfection agents

Abstract

ASJC Scopus subject areas

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