Following the N-alkylation reaction of starting 2-chloro-N-(5-aryl-1,3,4-oxadiazol-2-yl)-acetamides 1a-c with 2,4-thiazolidinedione or 5-sudstituted isatins the corresponding non-condensed oxadiazole derivatives with thiazolidine 2a-c or isatin 4a-h fragments were synthesized. The obtained compounds have been used in Knoevenagel condensation with 5R-isatin (for 2a-c) or 4-thiazolidinone derivatives (for 4a-h) for synthesis of the appropriate 5-ylidenederivatives 3a-g, 5a-k and 6a-d. Anticancer activity of eight synthesized compounds was evaluated toward 60 human tumor cell lines panel in National Cancer Institute.
|Number of pages||8|
|Journal||Chemistry and Chemical Technology|
|State||Published - 2015|
Bibliographical notePublisher Copyright:
© Lelyukh M., Havrylyuk D., Lesyk R., 2015.
- 1, 3, 4-oxadiazole
- Anticancer activity
- Knoevenagel condensation
ASJC Scopus subject areas
- Chemistry (all)
- Chemical Engineering (all)