Synthesis and anticancer activity of isatin, oxadiazole and 4-thiazolidinone based conjugates

Maryan Lelyukh, Dmytro Havrylyuk, Roman Lesyk

Research output: Contribution to journalArticlepeer-review

12 Scopus citations


Following the N-alkylation reaction of starting 2-chloro-N-(5-aryl-1,3,4-oxadiazol-2-yl)-acetamides 1a-c with 2,4-thiazolidinedione or 5-sudstituted isatins the corresponding non-condensed oxadiazole derivatives with thiazolidine 2a-c or isatin 4a-h fragments were synthesized. The obtained compounds have been used in Knoevenagel condensation with 5R-isatin (for 2a-c) or 4-thiazolidinone derivatives (for 4a-h) for synthesis of the appropriate 5-ylidenederivatives 3a-g, 5a-k and 6a-d. Anticancer activity of eight synthesized compounds was evaluated toward 60 human tumor cell lines panel in National Cancer Institute.

Original languageEnglish
Pages (from-to)29-36
Number of pages8
JournalChemistry and Chemical Technology
Issue number1
StatePublished - 2015

Bibliographical note

Publisher Copyright:
© Lelyukh M., Havrylyuk D., Lesyk R., 2015.


  • 1, 3, 4-oxadiazole
  • 4-thiazolidinone
  • Alkylation
  • Anticancer activity
  • Isatin
  • Knoevenagel condensation

ASJC Scopus subject areas

  • General Chemistry
  • General Chemical Engineering


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