Abstract
Potential trichothecene photoaffinity reagents were prepared by coupling either the C-4 or C-15 alcohols derived from anguidine with (3-azido-5-methoxyphenoxy) acetic acid, 4-(3-azido-5-methoxyphenoxy)butyric acid, or N-(3-azido-5-methoxyphenyl) N'-(carboxymethyl) urea. The C-15 anguidine deriviatives of (3-azido-5-methoxyphenoxy)acetic acid and (3-azido-4-iodo-5-methoxyphenoxy) acetic acid possessed protein synthesis inhibition activity comparable to that of anguidine itself in Chinese hamster ovary and African Green Monkey kidney cell lines.
| Original language | English |
|---|---|
| Pages (from-to) | 2925-2934 |
| Number of pages | 10 |
| Journal | Tetrahedron |
| Volume | 43 |
| Issue number | 13 |
| DOIs | |
| State | Published - 1987 |
Bibliographical note
Funding Information:This work was supported by a G-R-H Grant at the University of Kentucky and by the U. S. Army Medical Research Acquisition Agency, Contract No. DAMD17-85-C-5192. We thank Dr. Takushi Kaneko of Bristol-Myers Companyf or generous chemical gift, the Midwest Center for Mass Spectrometry for exact mass determinations, and David C. Hybner for technical assistance.
Funding
This work was supported by a G-R-H Grant at the University of Kentucky and by the U. S. Army Medical Research Acquisition Agency, Contract No. DAMD17-85-C-5192. We thank Dr. Takushi Kaneko of Bristol-Myers Companyf or generous chemical gift, the Midwest Center for Mass Spectrometry for exact mass determinations, and David C. Hybner for technical assistance.
| Funders | Funder number |
|---|---|
| U. S. Army Medical Research Acquisition Agency | |
| University of Kentucky |
ASJC Scopus subject areas
- Biochemistry
- Drug Discovery
- Organic Chemistry