Abstract
Ambradiolic acid (3) with oleanane skeleton is a natural pentacyclictriterpene. The first synthesis of 3 starting from 23-hydroxybetulinic acid (2) has been accomplished in 12-steps with a total yield of 18.1% in our study. Compound 3 was further biologically evaluated and found to exhibit significant inhibitory activity against rabbit muscle glycogen phosphorylase (GP) with an IC50 value of 12.4 μM, suggesting it could be a potential lead compound for the development of hypoglycemic drugs.
Original language | English |
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Pages (from-to) | 50-55 |
Number of pages | 6 |
Journal | Fitoterapia |
Volume | 100 |
DOIs | |
State | Published - Jan 2015 |
Bibliographical note
Publisher Copyright:© 2014 Elsevier B.V. All rights reserved.
Keywords
- 23-Hydroxybetulinic acid
- Ambradiolic acid
- First synthesis
- Glycogen phosphorylase (GP)
ASJC Scopus subject areas
- Pharmacology
- Drug Discovery