Synthesis and characterization of BODIPY-labeled colchicine

Leggy A. Arnold, Patricia Ranaivo, R. Kiplin Guy

Research output: Contribution to journalArticlepeer-review

7 Scopus citations


Two BODIPY-labeled colchicine derivatives were synthesized and shown to bind to tubulin but only partially inhibit tubulin polymerization in the presence of GTP. Cytotoxicity studies were carried out in HeLa, HepG2, Raji and Vero cells. Apoptosis-inducing properties were determined by caspase 3/7 activity and flow cytometry and interactions between the derivatives and tubulin were verified by fluorescence microscopy of living cells.

Original languageEnglish
Pages (from-to)5867-5870
Number of pages4
JournalBioorganic and Medicinal Chemistry Letters
Issue number22
StatePublished - Nov 15 2008

Bibliographical note

Funding Information:
This work was supported by the American Lebanese and Syrian Associated Charities (ALSAC), and St. Jude Children’s Research Hospital. We thank Michele Connelly for culturing the cell lines used.


  • Colchicine

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Medicine
  • Molecular Biology
  • Pharmaceutical Science
  • Drug Discovery
  • Clinical Biochemistry
  • Organic Chemistry


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