Synthesis and characterization of PEG-iron oxide core-shell composite nanoparticles for thermal therapy

Robert J. Wydra, Anastasia M. Kruse, Younsoo Bae, Kimberly W. Anderson, J. Zach Hilt

Research output: Contribution to journalArticlepeer-review

33 Scopus citations

Abstract

In this study, core-shell nanoparticleswere developed to achieve thermal therapy that can ablate cancer cells in a remotely controlled manner. The core-shell nanoparticleswere prepared using atomic transfer radical polymerization (ATRP) to coat iron oxide (Fe3O4) nanoparticles with a poly(ethylene glycol) (PEG) based polymer shell. The iron oxide core allows for the remote heating of the particles in an alternating magnetic field (AMF). The coating of iron oxide with PEG was verified through Fourier transforminfrared spectroscopy and thermal gravimetric analysis. A thermoablation (55 °C) study was performed on A549 lung carcinoma cells exposed to nanoparticles and over a 10 min AMF exposure. The successful thermoablation of A549 demonstrates the potential use of polymer coated particles for thermal therapy.

Original languageEnglish
Pages (from-to)4660-4666
Number of pages7
JournalMaterials Science and Engineering C
Volume33
Issue number8
DOIs
StatePublished - Dec 1 2013

Bibliographical note

Funding Information:
The authors acknowledge Dr. Li Chen of the University of Kentucky Biostatistics Shared Resource Facility for her assistance with the statistical analysis. This work was supported by the following National Science Foundation grants: NSF IGERT Training Grant (# DGE-0653710 ) and NSF REU Grant (# EEC-1156667 ).

Keywords

  • Atom transfer radical polymerization
  • Magnetic nanoparticles
  • Thermal therapy

ASJC Scopus subject areas

  • General Medicine

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