Synthesis and characterization of thermally responsive N-isopropylacrylamide hydrogels copolymerized with novel hydrophobic polyphenolic crosslinkers

Shuo Tang, Rohit Bhandari, Sean P. Delaney, Eric J. Munson, Thomas D. Dziubla, J. Zach Hilt

Research output: Contribution to journalArticlepeer-review

16 Scopus citations

Abstract

Two series of thermosensitive hydrogels were synthesized by copolymerizing N-isopropylacrylamide (NIPAAm) with various contents of novel hydrophobic crosslinkers, curcumin multiacrylate (CMA) and quercetin multiacrylate (QMA). The compositions of the resulting hydrogels were characterized using solid state-NMR (ss-NMR), and the temperature dependent swelling behavior and lower critical solution temperature (LCST) were characterized using swelling studies and differential scanning calorimetry (DSC). Increasing the crosslinker content resulted in a significant decrease in the LCST and swelling ratio of hydrogels, which could be attributed to the increased hydrophobicity introduced by CMA or QMA. All of the hydrogels demonstrated temperature responsive swelling with the extent of swelling decreasing with increasing crosslinker content. The lower crosslinker content gels displayed sharper phase transitions, while the high crosslinker content gels had broader phase transitions.

Original languageEnglish
Pages (from-to)46-53
Number of pages8
JournalMaterials Today Communications
Volume10
DOIs
StatePublished - Mar 1 2017

Bibliographical note

Publisher Copyright:
© 2017 Elsevier Ltd

ASJC Scopus subject areas

  • General Materials Science
  • Mechanics of Materials
  • Materials Chemistry

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