Synthesis and Characterization of Thermoresponsive Hydrogels Based on N-Isopropylacrylamide Crosslinked with 4,4′-Dihydroxybiphenyl Diacrylate

Shuo Tang; Martha Floy; Rohit Bhandari; Manjula Sunkara; Andrew J. Morris; Thomas D. Dziubla; J. Zach Hilt

doi:10.1021/acsomega.7b01247

Synthesis and Characterization of Thermoresponsive Hydrogels Based on N-Isopropylacrylamide Crosslinked with 4,4′-Dihydroxybiphenyl Diacrylate

Shuo Tang, Martha Floy, Rohit Bhandari, Manjula Sunkara, Andrew J. Morris, Thomas D. Dziubla, J. Zach Hilt

Research output: Contribution to journal › Article › peer-review

21 Scopus citations

Abstract

A novel crosslinker [4,4′-dihydroxybiphenyl diacrylate (44BDA)] was developed, and a series of temperature-responsive hydrogels were synthesized through free radical polymerization of N-isopropylacrylamide (NIPAAm) with 44BDA. The temperature-responsive behavior of the resulting gels was characterized by swelling studies, and the lower critical solution temperature (LCST) of the hydrogels was characterized through differential scanning calorimetry. Increased content of 44BDA led to a decreased swelling ratio and shifted the LCST to lower temperatures. These novel hydrogels also displayed resiliency through multiple swelling-deswelling cycles, and their temperature responsiveness was reversible. The successful synthesis of NIPAAm-based hydrogels crosslinked with 44BDA has led to a new class of temperature-responsive hydrogel systems with a variety of potential applications.

Original language	English
Pages (from-to)	8723-8729
Number of pages	7
Journal	ACS Omega
Volume	2
Issue number	12
DOIs	https://doi.org/10.1021/acsomega.7b01247
State	Published - Dec 31 2017

Bibliographical note

Funding Information:
This research has been generously supported by the NSF-REU grant EEC-1460486 and the NIEHS/NIH grant P42ES007380. The content is solely the responsibility of the authors and does not necessarily represent the official views of NIH.

Publisher Copyright:
© 2017 American Chemical Society.

ASJC Scopus subject areas

Chemistry (all)
Chemical Engineering (all)

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title = "Synthesis and Characterization of Thermoresponsive Hydrogels Based on N-Isopropylacrylamide Crosslinked with 4,4′-Dihydroxybiphenyl Diacrylate",

abstract = "A novel crosslinker [4,4′-dihydroxybiphenyl diacrylate (44BDA)] was developed, and a series of temperature-responsive hydrogels were synthesized through free radical polymerization of N-isopropylacrylamide (NIPAAm) with 44BDA. The temperature-responsive behavior of the resulting gels was characterized by swelling studies, and the lower critical solution temperature (LCST) of the hydrogels was characterized through differential scanning calorimetry. Increased content of 44BDA led to a decreased swelling ratio and shifted the LCST to lower temperatures. These novel hydrogels also displayed resiliency through multiple swelling-deswelling cycles, and their temperature responsiveness was reversible. The successful synthesis of NIPAAm-based hydrogels crosslinked with 44BDA has led to a new class of temperature-responsive hydrogel systems with a variety of potential applications.",

author = "Shuo Tang and Martha Floy and Rohit Bhandari and Manjula Sunkara and Morris, {Andrew J.} and Dziubla, {Thomas D.} and Hilt, {J. Zach}",

note = "Funding Information: This research has been generously supported by the NSF-REU grant EEC-1460486 and the NIEHS/NIH grant P42ES007380. The content is solely the responsibility of the authors and does not necessarily represent the official views of NIH. Publisher Copyright: {\textcopyright} 2017 American Chemical Society.",

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AU - Tang, Shuo

AU - Floy, Martha

AU - Bhandari, Rohit

AU - Sunkara, Manjula

AU - Morris, Andrew J.

AU - Dziubla, Thomas D.

AU - Hilt, J. Zach

N1 - Funding Information: This research has been generously supported by the NSF-REU grant EEC-1460486 and the NIEHS/NIH grant P42ES007380. The content is solely the responsibility of the authors and does not necessarily represent the official views of NIH. Publisher Copyright: © 2017 American Chemical Society.

PY - 2017/12/31

Y1 - 2017/12/31

N2 - A novel crosslinker [4,4′-dihydroxybiphenyl diacrylate (44BDA)] was developed, and a series of temperature-responsive hydrogels were synthesized through free radical polymerization of N-isopropylacrylamide (NIPAAm) with 44BDA. The temperature-responsive behavior of the resulting gels was characterized by swelling studies, and the lower critical solution temperature (LCST) of the hydrogels was characterized through differential scanning calorimetry. Increased content of 44BDA led to a decreased swelling ratio and shifted the LCST to lower temperatures. These novel hydrogels also displayed resiliency through multiple swelling-deswelling cycles, and their temperature responsiveness was reversible. The successful synthesis of NIPAAm-based hydrogels crosslinked with 44BDA has led to a new class of temperature-responsive hydrogel systems with a variety of potential applications.

AB - A novel crosslinker [4,4′-dihydroxybiphenyl diacrylate (44BDA)] was developed, and a series of temperature-responsive hydrogels were synthesized through free radical polymerization of N-isopropylacrylamide (NIPAAm) with 44BDA. The temperature-responsive behavior of the resulting gels was characterized by swelling studies, and the lower critical solution temperature (LCST) of the hydrogels was characterized through differential scanning calorimetry. Increased content of 44BDA led to a decreased swelling ratio and shifted the LCST to lower temperatures. These novel hydrogels also displayed resiliency through multiple swelling-deswelling cycles, and their temperature responsiveness was reversible. The successful synthesis of NIPAAm-based hydrogels crosslinked with 44BDA has led to a new class of temperature-responsive hydrogel systems with a variety of potential applications.

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Synthesis and Characterization of Thermoresponsive Hydrogels Based on N-Isopropylacrylamide Crosslinked with 4,4′-Dihydroxybiphenyl Diacrylate

Abstract

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