Synthesis and crystal structure of topiramate azidosulfate at 90 K and 298 K

Prabhakar Priyanka; Bidarur K. Jayanna; Haruvegowda Kiran Kumar; Vinaya; Thayamma R. Divakara; Hemmige S. Yathirajan; Christopher Glidewell; Sean Parkin

doi:10.1107/S2056989022008799

Synthesis and crystal structure of topiramate azidosulfate at 90 K and 298 K

Prabhakar Priyanka, Bidarur K. Jayanna, Haruvegowda Kiran Kumar, Vinaya, Thayamma R. Divakara, Hemmige S. Yathirajan, Christopher Glidewell, Sean Parkin

Chemistry

Research output: Contribution to journal › Article › peer-review

Abstract

The low (90 K) and room (298 K) temperature crystal structures of topiramate azidosulfate [systematic name 2,3:4,5-bis-O-(1-methylethylidene)-β-d-fructo-pyranose azidosulfate], C₁₂H₁₉N₃O₈S, an intermediate in the synthesis of the anti-convulsant drug topiramate, are described. Topiramate azidosulfate (I) finds use as a reference impurity standard for topiramate. A modified synthesis and some spectroscopic details are also presented.

Original language	English
Pages (from-to)	984-988
Number of pages	5
Journal	Acta Crystallographica Section E: Crystallographic Communications
Volume	78
Issue number	10
DOIs	https://doi.org/10.1107/S2056989022008799
State	Published - Oct 1 2022

Bibliographical note

Publisher Copyright:
© 2022 International Union of Crystallography. All rights reserved.

Keywords

absolute configuration
anti-convulsant
crystal structure
intermediate
topiramate azidosulfate

ASJC Scopus subject areas

General Chemistry
General Materials Science
Condensed Matter Physics

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10.1107/S2056989022008799

Cite this

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title = "Synthesis and crystal structure of topiramate azidosulfate at 90 K and 298 K",

abstract = "The low (90 K) and room (298 K) temperature crystal structures of topiramate azidosulfate [systematic name 2,3:4,5-bis-O-(1-methylethylidene)-β-d-fructo-pyranose azidosulfate], C12H19N3O8S, an intermediate in the synthesis of the anti-convulsant drug topiramate, are described. Topiramate azidosulfate (I) finds use as a reference impurity standard for topiramate. A modified synthesis and some spectroscopic details are also presented.",

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T1 - Synthesis and crystal structure of topiramate azidosulfate at 90 K and 298 K

AU - Priyanka, Prabhakar

AU - Jayanna, Bidarur K.

AU - Kumar, Haruvegowda Kiran

AU - Vinaya,

AU - Divakara, Thayamma R.

AU - Yathirajan, Hemmige S.

AU - Glidewell, Christopher

AU - Parkin, Sean

PY - 2022/10/1

Y1 - 2022/10/1

N2 - The low (90 K) and room (298 K) temperature crystal structures of topiramate azidosulfate [systematic name 2,3:4,5-bis-O-(1-methylethylidene)-β-d-fructo-pyranose azidosulfate], C12H19N3O8S, an intermediate in the synthesis of the anti-convulsant drug topiramate, are described. Topiramate azidosulfate (I) finds use as a reference impurity standard for topiramate. A modified synthesis and some spectroscopic details are also presented.

AB - The low (90 K) and room (298 K) temperature crystal structures of topiramate azidosulfate [systematic name 2,3:4,5-bis-O-(1-methylethylidene)-β-d-fructo-pyranose azidosulfate], C12H19N3O8S, an intermediate in the synthesis of the anti-convulsant drug topiramate, are described. Topiramate azidosulfate (I) finds use as a reference impurity standard for topiramate. A modified synthesis and some spectroscopic details are also presented.

KW - absolute configuration

KW - anti-convulsant

KW - crystal structure

KW - intermediate

KW - topiramate azidosulfate

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JO - Acta Crystallographica Section E: Crystallographic Communications

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Synthesis and crystal structure of topiramate azidosulfate at 90 K and 298 K

Abstract

Bibliographical note

Keywords

ASJC Scopus subject areas

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