Synthesis and crystal structure of topiramate azidosulfate at 90 K and 298 K

Prabhakar Priyanka, Bidarur K. Jayanna, Haruvegowda Kiran Kumar, Vinaya, Thayamma R. Divakara, Hemmige S. Yathirajan, Christopher Glidewell, Sean Parkin

Research output: Contribution to journalArticlepeer-review


The low (90 K) and room (298 K) temperature crystal structures of topiramate azidosulfate [systematic name 2,3:4,5-bis-O-(1-methylethylidene)-β-d-fructo-pyranose azidosulfate], C12H19N3O8S, an intermediate in the synthesis of the anti-convulsant drug topiramate, are described. Topiramate azidosulfate (I) finds use as a reference impurity standard for topiramate. A modified synthesis and some spectroscopic details are also presented.

Original languageEnglish
Pages (from-to)984-988
Number of pages5
JournalActa Crystallographica Section E: Crystallographic Communications
Issue number10
StatePublished - Oct 1 2022

Bibliographical note

Publisher Copyright:
© 2022 International Union of Crystallography. All rights reserved.


  • absolute configuration
  • anti-convulsant
  • crystal structure
  • intermediate
  • topiramate azidosulfate

ASJC Scopus subject areas

  • General Chemistry
  • General Materials Science
  • Condensed Matter Physics


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