Synthesis and photobiological evaluation of Ru(II) complexes with expanded chelate polypyridyl ligands

Raphael T. Ryan, Austin C. Hachey, Kimberly Stevens, Sean R. Parkin, Richard J. Mitchell, John P. Selegue, David K. Heidary, Edith C. Glazer

Research output: Contribution to journalArticlepeer-review

2 Scopus citations

Abstract

Photoreactive Ru(II) complexes capable of ejecting ligands have been used extensively for photocaging applications and for the creation of “photocisplatin” reagents. The incorporation of distortion into the structure of the coordination complex lowers the energy of dissociative excited states, increasing the yield of the photosubstitution reaction. While steric clash between ligands induced by adding substituents at the coordinating face of the ligand has been extensively utilized, a lesser known, more subtle approach is to distort the coordination sphere by altering the chelate ring size. Here a systematic study was performed to alter metal-ligand bond lengths, angles, and to cause intraligand distortion by introducing a “linker” atom or group between two pyridine rings. The synthesis, photochemistry, and photobiology of five Ru(II) complexes containing CH2, NH, O, and S-linked dipyridine ligands was investigated. All systems where stable in the dark, and three of the five were photochemically active in buffer. While a clear periodic trend was not observed, this study lays the foundation for the creation of photoactive systems utilizing an alternative type of distortion to facilitate photosubstitution reactions.

Original languageEnglish
Article number112031
JournalJournal of Inorganic Biochemistry
Volume238
DOIs
StatePublished - Jan 2023

Bibliographical note

Publisher Copyright:
© 2022

Keywords

  • DNA
  • Distortion
  • Photocage
  • Photochemistry
  • Ruthenium

ASJC Scopus subject areas

  • Biochemistry
  • Inorganic Chemistry

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