Synthesis and structure of 5,7-dimethylthieno[3,4-d]pyridazine

Nathan C. Tice, Sarah M. Peak, Sean Parkin

Research output: Contribution to journalArticlepeer-review

7 Scopus citations


The reaction of 2,5-dimethylthiophene-3,4-dicarboxaldehye (3) with excess hydrazine hydrate afforded the desired 5,6-fused ring thiophene derivative, 5,7-dimethylthieno[3,4-d]pyridazine (4), in high yield (82%). Pyridazine 4 was characterized spectroscopically and its structure was confirmed by X-ray crystallography. Compound 4 was observed to have an inverted, coplanar stacking arrangement in the solid state.

Original languageEnglish
Pages (from-to)1631-1639
Number of pages9
Issue number7
StatePublished - 2010

ASJC Scopus subject areas

  • Analytical Chemistry
  • Pharmacology
  • Organic Chemistry


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