Synthesis and turnover of 3H-5-hydroxytryptamine in the lateral cerebroventricle

K. M. Kantak; M. J. Wayner; H. A. Tilson; L. P. Dwoskin; J. M. Stein

doi:10.1016/0091-3057(78)90332-5

Synthesis and turnover of ³H-5-hydroxytryptamine in the lateral cerebroventricle

K. M. Kantak, M. J. Wayner, H. A. Tilson, L. P. Dwoskin, J. M. Stein

Research output: Contribution to journal › Article › peer-review

3 Scopus citations

Abstract

The lateral cerebroventricle was perfused using two different labelling procedures in three separate experiments on 5-hydroxytryptamine metabolism. The sensitivity of 5-hydroxytryptamine metabolism to various drugs was subsequently determined. The results demonstrate that two serotonin reuptake blockers, imipramine and fluoxetine, increase the efflux of ³H-5-hydroxytryptamine into the ventricle without affecting the efflux of ³H-5-hydroxyindoleacetic acid. BL-3912 A, a drug with weak serotonin agonist activity, also increased the efflux of ³H-5-hydroxytryptamine into the ventricle.

Original language	English
Pages (from-to)	153-161
Number of pages	9
Journal	Pharmacology Biochemistry and Behavior
Volume	8
Issue number	2
DOIs	https://doi.org/10.1016/0091-3057(78)90332-5
State	Published - Feb 1978

Bibliographical note

Funding Information:
This research was supported by NSF Grant BNS 74-01481, NIMH Training Grant MH-14258, and funding from the Syracuse University Senate Research Committee. 2 Send reprint requests to Professor Matthew J. Wayner, Syracuse University, 601 University Avenue, Syracuse, NY 13210.

Keywords

5-Hydroxyindoleacetic acid
5-Hydroxytryptamine
BL-3912A
Dimoxamine
Fluoxetine
Imipramine
Lateral cerebroventricle
Tryptophan

ASJC Scopus subject areas

Biochemistry
Toxicology
Pharmacology
Clinical Biochemistry
Biological Psychiatry
Behavioral Neuroscience

Access to Document

10.1016/0091-3057(78)90332-5

Cite this

@article{7e376456a4bb4657904d6874f9b0327e,

title = "Synthesis and turnover of 3H-5-hydroxytryptamine in the lateral cerebroventricle",

abstract = "The lateral cerebroventricle was perfused using two different labelling procedures in three separate experiments on 5-hydroxytryptamine metabolism. The sensitivity of 5-hydroxytryptamine metabolism to various drugs was subsequently determined. The results demonstrate that two serotonin reuptake blockers, imipramine and fluoxetine, increase the efflux of 3H-5-hydroxytryptamine into the ventricle without affecting the efflux of 3H-5-hydroxyindoleacetic acid. BL-3912 A, a drug with weak serotonin agonist activity, also increased the efflux of 3H-5-hydroxytryptamine into the ventricle.",

keywords = "5-Hydroxyindoleacetic acid, 5-Hydroxytryptamine, BL-3912A, Dimoxamine, Fluoxetine, Imipramine, Lateral cerebroventricle, Tryptophan",

author = "Kantak, {K. M.} and Wayner, {M. J.} and Tilson, {H. A.} and Dwoskin, {L. P.} and Stein, {J. M.}",

note = "Funding Information: This research was supported by NSF Grant BNS 74-01481, NIMH Training Grant MH-14258, and funding from the Syracuse University Senate Research Committee. 2 Send reprint requests to Professor Matthew J. Wayner, Syracuse University, 601 University Avenue, Syracuse, NY 13210.",

year = "1978",

month = feb,

doi = "10.1016/0091-3057(78)90332-5",

language = "English",

volume = "8",

pages = "153--161",

number = "2",

}

TY - JOUR

T1 - Synthesis and turnover of 3H-5-hydroxytryptamine in the lateral cerebroventricle

AU - Kantak, K. M.

AU - Wayner, M. J.

AU - Tilson, H. A.

AU - Dwoskin, L. P.

AU - Stein, J. M.

N1 - Funding Information: This research was supported by NSF Grant BNS 74-01481, NIMH Training Grant MH-14258, and funding from the Syracuse University Senate Research Committee. 2 Send reprint requests to Professor Matthew J. Wayner, Syracuse University, 601 University Avenue, Syracuse, NY 13210.

PY - 1978/2

Y1 - 1978/2

N2 - The lateral cerebroventricle was perfused using two different labelling procedures in three separate experiments on 5-hydroxytryptamine metabolism. The sensitivity of 5-hydroxytryptamine metabolism to various drugs was subsequently determined. The results demonstrate that two serotonin reuptake blockers, imipramine and fluoxetine, increase the efflux of 3H-5-hydroxytryptamine into the ventricle without affecting the efflux of 3H-5-hydroxyindoleacetic acid. BL-3912 A, a drug with weak serotonin agonist activity, also increased the efflux of 3H-5-hydroxytryptamine into the ventricle.

AB - The lateral cerebroventricle was perfused using two different labelling procedures in three separate experiments on 5-hydroxytryptamine metabolism. The sensitivity of 5-hydroxytryptamine metabolism to various drugs was subsequently determined. The results demonstrate that two serotonin reuptake blockers, imipramine and fluoxetine, increase the efflux of 3H-5-hydroxytryptamine into the ventricle without affecting the efflux of 3H-5-hydroxyindoleacetic acid. BL-3912 A, a drug with weak serotonin agonist activity, also increased the efflux of 3H-5-hydroxytryptamine into the ventricle.

KW - 5-Hydroxyindoleacetic acid

KW - 5-Hydroxytryptamine

KW - BL-3912A

KW - Dimoxamine

KW - Fluoxetine

KW - Imipramine

KW - Lateral cerebroventricle

KW - Tryptophan

UR - http://www.scopus.com/inward/record.url?scp=0018200417&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0018200417&partnerID=8YFLogxK

U2 - 10.1016/0091-3057(78)90332-5

DO - 10.1016/0091-3057(78)90332-5

M3 - Article

C2 - 652825

AN - SCOPUS:0018200417

SN - 0091-3057

VL - 8

SP - 153

EP - 161

JO - Pharmacology Biochemistry and Behavior

JF - Pharmacology Biochemistry and Behavior

IS - 2

ER -