The lateral cerebroventricle was perfused using two different labelling procedures in three separate experiments on 5-hydroxytryptamine metabolism. The sensitivity of 5-hydroxytryptamine metabolism to various drugs was subsequently determined. The results demonstrate that two serotonin reuptake blockers, imipramine and fluoxetine, increase the efflux of 3H-5-hydroxytryptamine into the ventricle without affecting the efflux of 3H-5-hydroxyindoleacetic acid. BL-3912 A, a drug with weak serotonin agonist activity, also increased the efflux of 3H-5-hydroxytryptamine into the ventricle.
|Number of pages||9|
|Journal||Pharmacology Biochemistry and Behavior|
|State||Published - Feb 1978|
Bibliographical noteFunding Information:
This research was supported by NSF Grant BNS 74-01481, NIMH Training Grant MH-14258, and funding from the Syracuse University Senate Research Committee. 2 Send reprint requests to Professor Matthew J. Wayner, Syracuse University, 601 University Avenue, Syracuse, NY 13210.
- 5-Hydroxyindoleacetic acid
- Lateral cerebroventricle
ASJC Scopus subject areas
- Clinical Biochemistry
- Biological Psychiatry
- Behavioral Neuroscience