Synthesis and turnover of 3H-5-hydroxytryptamine in the lateral cerebroventricle

K. M. Kantak; M. J. Wayner; H. A. Tilson; L. P. Dwoskin; J. M. Stein

doi:10.1016/0091-3057(78)90332-5

Synthesis and turnover of ³H-5-hydroxytryptamine in the lateral cerebroventricle

K. M. Kantak, M. J. Wayner, H. A. Tilson, L. P. Dwoskin, J. M. Stein

Research output: Contribution to journal › Article › peer-review

Abstract

The lateral cerebroventricle was perfused using two different labelling procedures in three separate experiments on 5-hydroxytryptamine metabolism. The sensitivity of 5-hydroxytryptamine metabolism to various drugs was subsequently determined. The results demonstrate that two serotonin reuptake blockers, imipramine and fluoxetine, increase the efflux of ³H-5-hydroxytryptamine into the ventricle without affecting the efflux of ³H-5-hydroxyindoleacetic acid. BL-3912 A, a drug with weak serotonin agonist activity, also increased the efflux of ³H-5-hydroxytryptamine into the ventricle.

Original language	English
Pages (from-to)	153-161
Number of pages	9
Journal	Pharmacology Biochemistry and Behavior
Volume	8
Issue number	2
DOIs	https://doi.org/10.1016/0091-3057(78)90332-5
State	Published - Feb 1978

Bibliographical note

Funding Information:
This research was supported by NSF Grant BNS 74-01481, NIMH Training Grant MH-14258, and funding from the Syracuse University Senate Research Committee. 2 Send reprint requests to Professor Matthew J. Wayner, Syracuse University, 601 University Avenue, Syracuse, NY 13210.

Keywords

5-Hydroxyindoleacetic acid
5-Hydroxytryptamine
BL-3912A
Dimoxamine
Fluoxetine
Imipramine
Lateral cerebroventricle
Tryptophan

ASJC Scopus subject areas

Biochemistry
Toxicology
Pharmacology
Clinical Biochemistry
Biological Psychiatry
Behavioral Neuroscience

Access to Document

10.1016/0091-3057(78)90332-5

Cite this

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title = "Synthesis and turnover of 3H-5-hydroxytryptamine in the lateral cerebroventricle",

abstract = "The lateral cerebroventricle was perfused using two different labelling procedures in three separate experiments on 5-hydroxytryptamine metabolism. The sensitivity of 5-hydroxytryptamine metabolism to various drugs was subsequently determined. The results demonstrate that two serotonin reuptake blockers, imipramine and fluoxetine, increase the efflux of 3H-5-hydroxytryptamine into the ventricle without affecting the efflux of 3H-5-hydroxyindoleacetic acid. BL-3912 A, a drug with weak serotonin agonist activity, also increased the efflux of 3H-5-hydroxytryptamine into the ventricle.",

keywords = "5-Hydroxyindoleacetic acid, 5-Hydroxytryptamine, BL-3912A, Dimoxamine, Fluoxetine, Imipramine, Lateral cerebroventricle, Tryptophan",

author = "Kantak, {K. M.} and Wayner, {M. J.} and Tilson, {H. A.} and Dwoskin, {L. P.} and Stein, {J. M.}",

note = "Funding Information: This research was supported by NSF Grant BNS 74-01481, NIMH Training Grant MH-14258, and funding from the Syracuse University Senate Research Committee. 2 Send reprint requests to Professor Matthew J. Wayner, Syracuse University, 601 University Avenue, Syracuse, NY 13210.",

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AU - Dwoskin, L. P.

AU - Stein, J. M.

N1 - Funding Information: This research was supported by NSF Grant BNS 74-01481, NIMH Training Grant MH-14258, and funding from the Syracuse University Senate Research Committee. 2 Send reprint requests to Professor Matthew J. Wayner, Syracuse University, 601 University Avenue, Syracuse, NY 13210.

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N2 - The lateral cerebroventricle was perfused using two different labelling procedures in three separate experiments on 5-hydroxytryptamine metabolism. The sensitivity of 5-hydroxytryptamine metabolism to various drugs was subsequently determined. The results demonstrate that two serotonin reuptake blockers, imipramine and fluoxetine, increase the efflux of 3H-5-hydroxytryptamine into the ventricle without affecting the efflux of 3H-5-hydroxyindoleacetic acid. BL-3912 A, a drug with weak serotonin agonist activity, also increased the efflux of 3H-5-hydroxytryptamine into the ventricle.

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