Abstract
The lateral cerebroventricle was perfused using two different labelling procedures in three separate experiments on 5-hydroxytryptamine metabolism. The sensitivity of 5-hydroxytryptamine metabolism to various drugs was subsequently determined. The results demonstrate that two serotonin reuptake blockers, imipramine and fluoxetine, increase the efflux of 3H-5-hydroxytryptamine into the ventricle without affecting the efflux of 3H-5-hydroxyindoleacetic acid. BL-3912 A, a drug with weak serotonin agonist activity, also increased the efflux of 3H-5-hydroxytryptamine into the ventricle.
Original language | English |
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Pages (from-to) | 153-161 |
Number of pages | 9 |
Journal | Pharmacology Biochemistry and Behavior |
Volume | 8 |
Issue number | 2 |
DOIs | |
State | Published - Feb 1978 |
Bibliographical note
Funding Information:This research was supported by NSF Grant BNS 74-01481, NIMH Training Grant MH-14258, and funding from the Syracuse University Senate Research Committee. 2 Send reprint requests to Professor Matthew J. Wayner, Syracuse University, 601 University Avenue, Syracuse, NY 13210.
Keywords
- 5-Hydroxyindoleacetic acid
- 5-Hydroxytryptamine
- BL-3912A
- Dimoxamine
- Fluoxetine
- Imipramine
- Lateral cerebroventricle
- Tryptophan
ASJC Scopus subject areas
- Biochemistry
- Toxicology
- Pharmacology
- Clinical Biochemistry
- Biological Psychiatry
- Behavioral Neuroscience