Synthesis and turnover of 3H-5-hydroxytryptamine in the lateral cerebroventricle

K. M. Kantak, M. J. Wayner, H. A. Tilson, L. P. Dwoskin, J. M. Stein

Research output: Contribution to journalArticlepeer-review

3 Scopus citations


The lateral cerebroventricle was perfused using two different labelling procedures in three separate experiments on 5-hydroxytryptamine metabolism. The sensitivity of 5-hydroxytryptamine metabolism to various drugs was subsequently determined. The results demonstrate that two serotonin reuptake blockers, imipramine and fluoxetine, increase the efflux of 3H-5-hydroxytryptamine into the ventricle without affecting the efflux of 3H-5-hydroxyindoleacetic acid. BL-3912 A, a drug with weak serotonin agonist activity, also increased the efflux of 3H-5-hydroxytryptamine into the ventricle.

Original languageEnglish
Pages (from-to)153-161
Number of pages9
JournalPharmacology Biochemistry and Behavior
Issue number2
StatePublished - Feb 1978

Bibliographical note

Funding Information:
This research was supported by NSF Grant BNS 74-01481, NIMH Training Grant MH-14258, and funding from the Syracuse University Senate Research Committee. 2 Send reprint requests to Professor Matthew J. Wayner, Syracuse University, 601 University Avenue, Syracuse, NY 13210.


  • 5-Hydroxyindoleacetic acid
  • 5-Hydroxytryptamine
  • BL-3912A
  • Dimoxamine
  • Fluoxetine
  • Imipramine
  • Lateral cerebroventricle
  • Tryptophan

ASJC Scopus subject areas

  • Biochemistry
  • Toxicology
  • Pharmacology
  • Clinical Biochemistry
  • Biological Psychiatry
  • Behavioral Neuroscience


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