Synthesis of biologically active taxoids

K. C. Nicolaou; R. K. Guy

doi:10.1201/9781420008272

Synthesis of biologically active taxoids

K. C. Nicolaou
, R. K. Guy

Research output: Chapter in Book/Report/Conference proceeding › Chapter › peer-review

Abstract

Taxol® (Figure 7.1; 1), a diterpene originally isolated from the American Pacific yew Taxus brevifolia,1 has emerged as one of the most effective chemotherapeutic agents for the treatment of breast and ovarian cancers.2 The compound is also in development for non-small-cell lung cancers,3 and head and neck cancers.4 Taxol’s development has included periods of both unusual languor and speed.5 It acts by blocking the normal depolymerization of microtubules, a process that is crucial for a number of cellular functions including mitosis.6 The elucidation of this unique mechanism by Horwitz’s group in the early 1980s spurred the drug’s development.7.

Original language	English
Title of host publication	Chemistry and Molecular Aspects of Drug Design and Action
Pages	101-108
Number of pages	8
ISBN (Electronic)	9781420008272
DOIs	https://doi.org/10.1201/9781420008272
State	Published - Jan 1 2008

Bibliographical note

Publisher Copyright:
© 2008 by Taylor & Francis Group, LLC.

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

ASJC Scopus subject areas

General Chemistry
General Pharmacology, Toxicology and Pharmaceutics
General Medicine

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10.1201/9781420008272

Cite this

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AB - Taxol® (Figure 7.1; 1), a diterpene originally isolated from the American Pacific yew Taxus brevifolia,1 has emerged as one of the most effective chemotherapeutic agents for the treatment of breast and ovarian cancers.2 The compound is also in development for non-small-cell lung cancers,3 and head and neck cancers.4 Taxol’s development has included periods of both unusual languor and speed.5 It acts by blocking the normal depolymerization of microtubules, a process that is crucial for a number of cellular functions including mitosis.6 The elucidation of this unique mechanism by Horwitz’s group in the early 1980s spurred the drug’s development.7.

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ER -

Synthesis of biologically active taxoids

Abstract

Bibliographical note

UN SDGs

ASJC Scopus subject areas

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