Abstract
(Equation Presented) Historically, general convergent syntheses of medium ring heterocycles have been difficult to develop. Herein, we describe the synthesis of five classes of heterocycles: dihydrodibenzo[b,f]azepine, -oxocine, and -thiocine and dibenzo[b,f]azepine and -oxepine using a strategy of alkylation followed by highly selective intramolecular Heck arylation reaction. The hetero-tricyclic compounds were available in only two steps starting from commercially available starting materials.
| Original language | English |
|---|---|
| Pages (from-to) | 3005-3007 |
| Number of pages | 3 |
| Journal | Organic Letters |
| Volume | 6 |
| Issue number | 17 |
| DOIs | |
| State | Published - Aug 19 2004 |
Funding
| Funders | Funder number |
|---|---|
| National Institute of Diabetes and Digestive and Kidney Diseases | R01DK058080 |
ASJC Scopus subject areas
- Biochemistry
- Physical and Theoretical Chemistry
- Organic Chemistry