Synthesis of new 4-azolidinones with 3,5-diaryl-4,5-dihydropyrazole moiety and evaluation of their antitumor activity in vitro

Dmytro Havrylyuk; Nataliya Kovach; Borys Zimenkovsky; Roman Lesyk

Synthesis of new 4-azolidinones with 3,5-diaryl-4,5-dihydropyrazole moiety and evaluation of their antitumor activity in vitro

Dmytro Havrylyuk, Nataliya Kovach, Borys Zimenkovsky, Roman Lesyk

Chemistry

Research output: Contribution to journal › Article › peer-review

6 Scopus citations

Abstract

In the present paper, a synthetic approach for design of new pyrazolme substituted 4-azolidones were described. Six of the synthesized compounds were tested according to NCI protocol and two of them (4d, 4e) displayed antitumor activity on leukemia, melanoma, lung, colon, CNS, ovarian, renal, prostate and breast cancers cell lines.

Original language	English
Pages (from-to)	173-177
Number of pages	5
Journal	Annales Universitatis Mariae Curie-Sklodowska, Sectio DDD: Pharmacia
Volume	23
Issue number	3
State	Published - 2010

Keywords

3,5-diaryl-4,5-dihydropyrazoles
4-azolidmones
Acylation
Alkylation
Antitumor activity
H NMR spectra

ASJC Scopus subject areas

Biochemistry
Molecular Biology
Pharmacology

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Cite this

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title = "Synthesis of new 4-azolidinones with 3,5-diaryl-4,5-dihydropyrazole moiety and evaluation of their antitumor activity in vitro",

abstract = "In the present paper, a synthetic approach for design of new pyrazolme substituted 4-azolidones were described. Six of the synthesized compounds were tested according to NCI protocol and two of them (4d, 4e) displayed antitumor activity on leukemia, melanoma, lung, colon, CNS, ovarian, renal, prostate and breast cancers cell lines.",

keywords = "3,5-diaryl-4,5-dihydropyrazoles, 4-azolidmones, Acylation, Alkylation, Antitumor activity, H NMR spectra",

author = "Dmytro Havrylyuk and Nataliya Kovach and Borys Zimenkovsky and Roman Lesyk",

year = "2010",

language = "English",

volume = "23",

pages = "173--177",

number = "3",

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TY - JOUR

T1 - Synthesis of new 4-azolidinones with 3,5-diaryl-4,5-dihydropyrazole moiety and evaluation of their antitumor activity in vitro

AU - Havrylyuk, Dmytro

AU - Kovach, Nataliya

AU - Zimenkovsky, Borys

AU - Lesyk, Roman

PY - 2010

Y1 - 2010

N2 - In the present paper, a synthetic approach for design of new pyrazolme substituted 4-azolidones were described. Six of the synthesized compounds were tested according to NCI protocol and two of them (4d, 4e) displayed antitumor activity on leukemia, melanoma, lung, colon, CNS, ovarian, renal, prostate and breast cancers cell lines.

AB - In the present paper, a synthetic approach for design of new pyrazolme substituted 4-azolidones were described. Six of the synthesized compounds were tested according to NCI protocol and two of them (4d, 4e) displayed antitumor activity on leukemia, melanoma, lung, colon, CNS, ovarian, renal, prostate and breast cancers cell lines.

KW - 3,5-diaryl-4,5-dihydropyrazoles

KW - 4-azolidmones

KW - Acylation

KW - Alkylation

KW - Antitumor activity

KW - H NMR spectra

UR - http://www.scopus.com/inward/record.url?scp=84860479489&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84860479489&partnerID=8YFLogxK

M3 - Article

AN - SCOPUS:84860479489

SN - 0867-0609

VL - 23

SP - 173

EP - 177

JO - Annales Universitatis Mariae Curie-Sklodowska, Sectio DDD: Pharmacia

JF - Annales Universitatis Mariae Curie-Sklodowska, Sectio DDD: Pharmacia

IS - 3

ER -

Synthesis of new 4-azolidinones with 3,5-diaryl-4,5-dihydropyrazole moiety and evaluation of their antitumor activity in vitro

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

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