Synthesis of O- and N-alkylated products of 1,2,3,4-tetrahydrobenzo[c][2,7]naphthyrin-5(6H)-one

Shobanbabu Bommagani, Na Ra Lee, Xuan Zhang, Linda P. Dwoskin, Guangrong Zheng

Research output: Contribution to journalArticlepeer-review

1 Scopus citations

Abstract

Efficient syntheses of O- and N-alkylated products of 1,2,3,4-tetrahydrobenzo[c][2,7]naphthyrin-5(6H)-one are presented. The O-alkylated analogues were synthesized through a reduction-cyclization cascade and a selective O-alkylation reaction; whereas the N-alkylated analogues were obtained through a key Buchwald coupling.

Original languageEnglish
Pages (from-to)6472-6474
Number of pages3
JournalTetrahedron Letters
Volume56
Issue number46
DOIs
StatePublished - Nov 18 2015

Bibliographical note

Funding Information:
This work was supported by funding from the National Institute of Health ( DA030667 and UL1 TR000117 ).

Publisher Copyright:
© 2015 Elsevier Ltd.

Keywords

  • 1,2,3,4-Tetrahydrobenzo[c][2,7]naphthyrin-5(6H)-one
  • Buchwald coupling
  • Muscarinic acetylcholine receptors
  • Reduction-cyclization cascade
  • Suzuki coupling

ASJC Scopus subject areas

  • Biochemistry
  • Drug Discovery
  • Organic Chemistry

Fingerprint

Dive into the research topics of 'Synthesis of O- and N-alkylated products of 1,2,3,4-tetrahydrobenzo[c][2,7]naphthyrin-5(6H)-one'. Together they form a unique fingerprint.

Cite this