Efficient syntheses of O- and N-alkylated products of 1,2,3,4-tetrahydrobenzo[c][2,7]naphthyrin-5(6H)-one are presented. The O-alkylated analogues were synthesized through a reduction-cyclization cascade and a selective O-alkylation reaction; whereas the N-alkylated analogues were obtained through a key Buchwald coupling.
|Number of pages||3|
|State||Published - Nov 18 2015|
Bibliographical noteFunding Information:
This work was supported by funding from the National Institute of Health ( DA030667 and UL1 TR000117 ).
© 2015 Elsevier Ltd.
- Buchwald coupling
- Muscarinic acetylcholine receptors
- Reduction-cyclization cascade
- Suzuki coupling
ASJC Scopus subject areas
- Drug Discovery
- Organic Chemistry