Abstract
Polyethylene glycol-polycation block copolymers, in which various kind of cationic side chains were introduced, were successfully synthesized by aminolysis of benzyl ester of polyethylene glycol-poly(β- benzyl-L-aspartate) block copolymer(PEG-PBLA)(ester-amide exchange method). Among them, some block copolymers showed the high transfection efficiency, and the mechanism and the characteristics of the ester-amide exchange reaction were investigated. This method is a very useful tool for design of non-viral gene carriers.
Original language | English |
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Pages | 2208 |
Number of pages | 1 |
State | Published - 2005 |
Event | 54th SPSJ Annual Meeting 2005 - Yokohama, Japan Duration: May 25 2005 → May 27 2005 |
Conference
Conference | 54th SPSJ Annual Meeting 2005 |
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Country/Territory | Japan |
City | Yokohama |
Period | 5/25/05 → 5/27/05 |
Keywords
- Block Copolymer
- Ester-Amide Exchange
- Gene Carrier
- Polyaspartamide
- Polyethylene Glycol
ASJC Scopus subject areas
- General Engineering