TY - JOUR
T1 - Synthesis of salvinorin A analogues as opioid receptor probes
AU - Tidgewell, Kevin
AU - Harding, Wayne W.
AU - Lozama, Anthony
AU - Cobb, Howard
AU - Shah, Kushal
AU - Kannan, Pavitra
AU - Dersch, Christina M.
AU - Parrish, Damon
AU - Deschamps, Jeffrey R.
AU - Rothman, Richard B.
AU - Prisinzano, Thomas E.
PY - 2006/6
Y1 - 2006/6
N2 - Several neoclerodanes, such as salvinorin A (1) and herkinorin (3), have recently been shown to possess opioid receptor activity in vitro and in vivo. To explore the structure-affinity relationships of this interesting class of compounds, we have synthesized a series of analogues from 1 isolated from Salvia divinorum. Here, we report the semisynthesis of neoclerodane diterpenes and their structure-affinity relationships at opioid receptors. This work will allow the further development of novel opioid receptor ligands.
AB - Several neoclerodanes, such as salvinorin A (1) and herkinorin (3), have recently been shown to possess opioid receptor activity in vitro and in vivo. To explore the structure-affinity relationships of this interesting class of compounds, we have synthesized a series of analogues from 1 isolated from Salvia divinorum. Here, we report the semisynthesis of neoclerodane diterpenes and their structure-affinity relationships at opioid receptors. This work will allow the further development of novel opioid receptor ligands.
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U2 - 10.1021/np060094b
DO - 10.1021/np060094b
M3 - Article
C2 - 16792410
AN - SCOPUS:33746557349
SN - 0163-3864
VL - 69
SP - 914
EP - 918
JO - Journal of Natural Products
JF - Journal of Natural Products
IS - 6
ER -