Many membrane-resident and secreted proteins, including growth factors and their receptors are N-glycosylated. The initial N-glycan structure is synthesized in the endoplasmic reticulum (ER) as a branched structure on a lipid anchor (dolicholpyrophosphate) and then co-translationally, “en bloc” transferred and linked via N-acetylglucosamine to asparagine within a specific N-glycosylation acceptor sequence of the nascent recipient protein. In the ER and then the Golgi apparatus, the N-linked glycan structure is modified by hydrolytic removal of sugar residues (“trimming”) followed by re-glycosylation with additional sugar residues (“processing”) such as galactose, fucose or sialic acid to form complex N-glycoproteins. While the sequence of the reactions leading to biosynthesis, “en bloc” transfer and processing of N-glycans is well investigated, it is still not completely understood how N-glycans affect the biological fate and function of N-glycoproteins. This review will discuss the biology of N-glycoprotein synthesis, processing and function with specific reference to the physiology and pathophysiology of the immune and nervous system, as well as infectious diseases such as Covid-19.
|Title of host publication||Advances in Neurobiology|
|Number of pages||29|
|State||Published - 2023|
|Name||Advances in Neurobiology|
Bibliographical noteFunding Information:
Acknowledgements This work was supported in part by NIH grants R01NS095215, R01AG034389, and R01AG064234, and the VA grant I01BX003643. I also thank the Department of Physiology (Chair Dr. Alan Daugherty), University of Kentucky Medical School for institutional support.
This work was supported in part by NIH grants R01NS095215, R01AG034389, and R01AG064234, and the VA grant I01BX003643. I also thank the Department of Physiology (Chair Dr. Alan Daugherty), University of Kentucky Medical School for institutional support.
© 2023, The Author(s), under exclusive license to Springer Nature Switzerland AG.
- Congenital disorders of glycosylation
ASJC Scopus subject areas
- Developmental Neuroscience
- Cellular and Molecular Neuroscience