Systematic review: Pancreatic enzyme treatment of malabsorption associated with chronic pancreatitis

A. K. Waljee, M. J. Dimagno, B. U. Wu, P. S. Schoenfeld, D. L. Conwell

Research output: Contribution to journalReview articlepeer-review

28 Scopus citations


Background: Pancreatic enzyme supplementation is standard treatment for malabsorption caused by chronic pancreatitis. The FDA recently required all manufacturers to submit New Drug Applications to continue to market these agents because published data demonstrated variation in formulation, bioavailability and shelf-life while providing limited data about efficacy and safety. Aim: To review systematically the design and results of randomized, parallel-design trials of pancreatic enzyme supplements in chronic pancreatitis patients with steatorrhea. Methods: A computer-assisted search of MEDLINE and EMBASE was performed to identify relevant studies. Two authors performed duplicate data extraction on study design, improvement in coefficient of fat absorption (CFA), diarrhoea and adverse events using pre-specified forms. Agreement between investigators for data extraction was greater than 95%. Results: Of 619 articles found through literature searching, 20 potentially relevant articles were identified and four manuscripts met inclusion criteria. No studies performed head-to-head comparisons of different supplements. Enzyme supplementation is more likely to improve CFA compared with placebo, but fat malabsorption remained abnormal. Important differences in patient population, study endpoint, study design, pancreatic enzyme dosage and measurement of CFA were present across trials, which precluded comparison of different agents. Conclusions: Enzyme supplementation improves CFA compared to placebo, but may not abolish steatorrhoea.

Original languageEnglish
Pages (from-to)235-246
Number of pages12
JournalAlimentary Pharmacology and Therapeutics
Issue number3
StatePublished - Feb 2009

ASJC Scopus subject areas

  • Hepatology
  • Gastroenterology
  • Pharmacology (medical)


Dive into the research topics of 'Systematic review: Pancreatic enzyme treatment of malabsorption associated with chronic pancreatitis'. Together they form a unique fingerprint.

Cite this