Abstract
We show here that T cell cross-reactivity between heterologous viruses influences the immunodominance of virus-specific CD8+ T cells by two mechanisms. First, T cells specific for cross-reactive epitopes dominate acute responses to viral infections; second, within the memory pool, T cells specific for cross-reactive epitopes are maintained while those specific for non-cross-reactive epitopes are selectively lost. These findings suggest an immunological paradigm in which viral infections shape the available T cell repertoire, causing alterations in the hierarchies of both the primary and memory CD8+ T cell responses elicited by subsequent viral infections. Thus, immunodominance is a function of the host's previous exposure to unrelated pathogens, and this may have an impact on protective immunity and immunopathology.
Original language | English |
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Pages (from-to) | 627-634 |
Number of pages | 8 |
Journal | Nature Immunology |
Volume | 3 |
Issue number | 7 |
DOIs | |
State | Published - 2002 |
Bibliographical note
Funding Information:Acknowledgments We thank B. S. Sheridan for excellent technical assistance. Supported by National Institutes of Health research grants AR-35506,AI-17672 and AI-46629 (to R. M.W.),AI-46578 (to L. K. S.),AI-29575,AI-44129 and NMSS (RG 2637 A2/1) (to J. P. S.); training grant AI-07439 (to M.A. B.) and, in part, by a center grant DK-32520.
ASJC Scopus subject areas
- Immunology and Allergy
- Immunology