T helper cells

Randolph Noelle; E. Charles Snow

doi:10.1016/0952-7915(92)90085-S

T helper cells

Randolph Noelle, E. Charles Snow

Microbiology, Immunology, and Molecular Genetics

Research output: Contribution to journal › Article › peer-review

32 Scopus citations

Abstract

B-cell proliferation and differentiation is controlled by T helper cells. Recent studies have determined that the expression of a novel, 39 kD, T-cell membrane protein is responsible for inducing T-cell-dependent B-cell activation. The receptor for this protein on the resting B cell is CD40. Once activated, B cells are induced to grow and differentiate by the elaboration of interleukin-4 and interleukin-5 from activated T cells. Together, T cell-B cell contact and soluble factors provide all the signals required for B-cell growth and differentiation.

Original language	English
Pages (from-to)	333-337
Number of pages	5
Journal	Current Opinion in Immunology
Volume	4
Issue number	3
DOIs	https://doi.org/10.1016/0952-7915(92)90085-S
State	Published - Jun 1992

ASJC Scopus subject areas

Immunology and Allergy
Immunology

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10.1016/0952-7915(92)90085-S

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title = "T helper cells",

abstract = "B-cell proliferation and differentiation is controlled by T helper cells. Recent studies have determined that the expression of a novel, 39 kD, T-cell membrane protein is responsible for inducing T-cell-dependent B-cell activation. The receptor for this protein on the resting B cell is CD40. Once activated, B cells are induced to grow and differentiate by the elaboration of interleukin-4 and interleukin-5 from activated T cells. Together, T cell-B cell contact and soluble factors provide all the signals required for B-cell growth and differentiation.",

author = "Randolph Noelle and Snow, {E. Charles}",

year = "1992",

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AU - Snow, E. Charles

PY - 1992/6

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N2 - B-cell proliferation and differentiation is controlled by T helper cells. Recent studies have determined that the expression of a novel, 39 kD, T-cell membrane protein is responsible for inducing T-cell-dependent B-cell activation. The receptor for this protein on the resting B cell is CD40. Once activated, B cells are induced to grow and differentiate by the elaboration of interleukin-4 and interleukin-5 from activated T cells. Together, T cell-B cell contact and soluble factors provide all the signals required for B-cell growth and differentiation.

AB - B-cell proliferation and differentiation is controlled by T helper cells. Recent studies have determined that the expression of a novel, 39 kD, T-cell membrane protein is responsible for inducing T-cell-dependent B-cell activation. The receptor for this protein on the resting B cell is CD40. Once activated, B cells are induced to grow and differentiate by the elaboration of interleukin-4 and interleukin-5 from activated T cells. Together, T cell-B cell contact and soluble factors provide all the signals required for B-cell growth and differentiation.

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T helper cells

Abstract

ASJC Scopus subject areas

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