T helper cells

Randolph Noelle, E. Charles Snow

Research output: Contribution to journalArticlepeer-review

32 Scopus citations


B-cell proliferation and differentiation is controlled by T helper cells. Recent studies have determined that the expression of a novel, 39 kD, T-cell membrane protein is responsible for inducing T-cell-dependent B-cell activation. The receptor for this protein on the resting B cell is CD40. Once activated, B cells are induced to grow and differentiate by the elaboration of interleukin-4 and interleukin-5 from activated T cells. Together, T cell-B cell contact and soluble factors provide all the signals required for B-cell growth and differentiation.

Original languageEnglish
Pages (from-to)333-337
Number of pages5
JournalCurrent Opinion in Immunology
Issue number3
StatePublished - Jun 1992

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology


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