Abstract
The T lymphocyte β2-adrenergic receptor (β2AR) density and function were compared in 15 patients suffering acute myocardial infarction and 10 patients with stable coronary artery disease (CAD). Density was determined using radioligand binding with 125IPIN, and function by in vitro cyclic adenosine 3',5'-monophosphate (cAMP) production. In patients suffering acute myocardial infarction, T lymphocyte β2AR density (823.8 ± 480 sites/cell) was slightly but not significantly different from that in patients with stable CAD (629 ± 301 sites/cell). There was no difference in T lymphocyte cAMP production at baseline (1.11 ± 0.70 vs 1.04 ± 0.49 pM/106 cells) or after isoproterenol stimulation (2.53 ± 1.63 vs 2.62 ± 2.05 pM/106 cells), respectively. Further study is necessary to determine if β2AR numbers on T lymphocytes are significantly increased after acute myocardial infarction.
Original language | English |
---|---|
Pages (from-to) | 357-362 |
Number of pages | 6 |
Journal | Pharmacotherapy |
Volume | 17 |
Issue number | 2 |
DOIs | |
State | Published - 1997 |
ASJC Scopus subject areas
- Pharmacology (medical)