T lymphocyte β2-adrenergic receptor function and density after acute myocardial infarction

Randall A. McCoy, G. Dennis Clifton, David C. Booth, Laura A. Bartels, Mary H.H. Chandler

Research output: Contribution to journalArticlepeer-review

1 Scopus citations

Abstract

The T lymphocyte β2-adrenergic receptor (β2AR) density and function were compared in 15 patients suffering acute myocardial infarction and 10 patients with stable coronary artery disease (CAD). Density was determined using radioligand binding with 125IPIN, and function by in vitro cyclic adenosine 3',5'-monophosphate (cAMP) production. In patients suffering acute myocardial infarction, T lymphocyte β2AR density (823.8 ± 480 sites/cell) was slightly but not significantly different from that in patients with stable CAD (629 ± 301 sites/cell). There was no difference in T lymphocyte cAMP production at baseline (1.11 ± 0.70 vs 1.04 ± 0.49 pM/106 cells) or after isoproterenol stimulation (2.53 ± 1.63 vs 2.62 ± 2.05 pM/106 cells), respectively. Further study is necessary to determine if β2AR numbers on T lymphocytes are significantly increased after acute myocardial infarction.

Original languageEnglish
Pages (from-to)357-362
Number of pages6
JournalPharmacotherapy
Volume17
Issue number2
DOIs
StatePublished - 1997

ASJC Scopus subject areas

  • Pharmacology (medical)

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